Anarid Capsule 0.5 Milligram (Anagrelide Hydrochloride)

Adult dose

In adults, the starting dose is 0.5mg 4 times daily or 1.0mg 2 times daily, administered with close monitoring and maintained for at least 1 week. In both adults and children, the dose should be the lowest effective dose necessary to reduce the platelet count to 600,000/μL or less, while keeping the platelet count within the normal range as much as possible. If the dose is increased, the amount of the increase should be no more than 0.5mg/day, and the dose should not be increased again within 1 week of that increase. The maintenance dose is the same for adult and pediatric patients. Do not exceed 2.5mg as a single dose or 10mg as the total daily dose. To monitor the effect of this medicine and prevent the onset of thrombocytopenia, check the platelet count every 2 days during the first week of treatment and at least once weekly after reaching the maintenance dose. In general, the platelet count begins to decrease within 7～14 days at the appropriate dose. It takes 4～12 weeks to achieve a complete response, defined as a platelet count of 600,000/μL or less. Most patients will show an adequate response with a dose of 1.5～3.0mg/day.

Child dose

The starting dose for children ranges from 0.5 mg once daily to 0.5 mg 4 times daily; based on limited data, an initial dose of 0.5 mg once daily is recommended for children.

This drug should not be used in patients with severe liver dysfunction, as it may significantly increase the drug concentration in patients with moderate to severe impairment of liver function. It should also not be administered to patients with genetic disorders impacting lactose digestion due to the lactose contained in this drug. Caution is necessary when using this drug in patients with suspected or existing heart disease, as it may increase heart rate and enhance cardiac contractility, potentially placing strain on the heart. Even in patients with normal cardiac health, heart-related side effects may occur, hence cardiac evaluations should be conducted before and during treatment to monitor for these effects. Patients with mild to moderate liver impairment require dosage adjustments and careful monitoring of liver function and cardiovascular status. Side effects related to interstitial lung disease or pulmonary hypertension have been reported, necessitating assessment of respiratory symptoms before and during treatment. Common side effects during treatment may include headache, palpitations, edema, nausea, diarrhea, dizziness, depression, memory loss, confusion, insomnia, paresthesia, sensory loss, neurosis, dry mouth, migraine, stuttering, drowsiness, abnormal coordination, diplopia, visual disturbances, tinnitus, increased blood pressure, nausea, gastrointestinal disorders, loss of appetite, dyspepsia, constipation, gastrointestinal diseases, rash, alopecia, pruritus, skin discoloration, dry skin, arthralgia, myalgia, lumbar pain, erectile dysfunction, nocturia. Platelet levels can fluctuate quickly upon discontinuation of this drug, thus, platelet levels should be monitored frequently. Sudden cessation of the drug may lead to severe complications such as thrombosis and should be avoided. Regular blood tests, liver function tests, kidney function tests, and electrolyte tests should be conducted during treatment to confirm any abnormal findings. Blood pressure may drop, so be mindful of symptoms such as dizziness. When combining with other medications that increase the risk of bleeding, such as aspirin, careful evaluation of the risks and benefits before concurrent use is necessary. This drug should not be administered to pregnant women or those who could become pregnant during treatment. Women are advised to avoid pregnancy while using this medication. Breastfeeding women should consider discontinuing either breastfeeding or the medication, as it may be secreted in breast milk. No special dosage adjustments are needed when treating children or elderly patients, though elderly patients may be at higher risk for heart-related side effects and should be monitored closely. In cases of overdose, a reduction in platelet count and cardiovascular and central nervous system toxicities may occur, necessitating immediate medical supervision. This medication should be kept out of reach of children, and caution is needed when transferring to other containers as this may affect its quality.

Headache, palpitations, fluid retention, nausea, diarrhea, anemia, pancytopenia, thrombocytopenia, bleeding, purpura, edema, weight loss, weight gain, dizziness, depression, forgetfulness, confusion, insomnia, abnormal sensations, sensory decrease, neurosis, dry mouth, migraine, stuttering, drowsiness, abnormal coordination, cerebral infarction, double vision, vision abnormalities, tinnitus, tachycardia, ventricular tachycardia, congestive heart failure, atrial fibrillation, supraventricular tachycardia, arrhythmia, hypertension, syncope, myocardial infarction, cardiomyopathy, cardiac hypertrophy, cardiac effusion, angina, orthostatic hypotension, vasodilation, Prinzmetal angina, Torsade de pointes, pulmonary hypertension, pneumonia, pleural effusion, dyspnea, epistaxis, pulmonary infiltrates, interstitial lung disease including pneumonia and allergic alveolitis, vomiting, abdominal pain, nausea, intestinal pneumatosis, gastrointestinal bleeding, pancreatitis, loss of appetite, dyspepsia, constipation, gastrointestinal disease, colitis, gastritis, gum bleeding, increased liver enzymes, hepatitis, rash, alopecia, pruritus, skin discoloration, dry skin, arthralgia, myalgia, low back pain, erectile dysfunction, renal failure, nocturia, tubulointerstitial nephritis, fatigue, chest pain, fever, chills, lethargy, weakness, flu-like symptoms pain, asthenia, increased blood creatinine, thrombosis, urinary tract infection symptoms, chest discomfort, right upper abdominal pain, rectal bleeding, increased ALP, acute renal failure, leukopenia, peripheral edema, neuropathy, nail changes, photosensitivity, increased white blood cell count, fever, epistaxis, back pain, muscle cramps, reduced mobility, loose stools, loss of appetite

This drug may be sensitive to air and light, hence it should be stored in a tightly closed container. Additionally, avoid direct sunlight and store in a cool room temperature ranging from 15 to 25 degrees Celsius.

Appearance

A white powder filled in white hard capsules with upper and lower parts

Package unit

30 capsules/bottle, 100 capsules/bottle