Cefar Tablet 250 mg (Cefuroxime Axetil)

Adult dose

For optimal absorption, this medicine should be taken after meals. Most infections: Administer 250mg twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms: Administer 500mg twice daily. Urinary tract infections: Administer 250mg twice daily. Uncomplicated gonorrhea: Administer a single dose of 1g. Lyme disease: Administer 500mg twice daily for 14 days (10~21 days). For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic streptococci), this medicine should be administered for 7~10 days. Patients with renal impairment: Creatinine clearance ≥ 30 mL/min/1.73m2, T1/2 (hours) 1.4 - 2.4: No dosage adjustment is necessary (standard dose: 125mg-500mg twice daily) Patients with renal impairment: Creatinine clearance 10 - 29 mL/min/1.73m2, T1/2 (hours) 4.6: Administer the standard single dose every 24 hours Patients with renal impairment: Creatinine clearance < 10 mL/min/1.73m2, T1/2 (hours) 16.8: Administer the standard single dose every 48 hours Patients undergoing hemodialysis: T1/2 (hours) 2 - 4: Administer an additional standard single dose at the end of each dialysis session

Child dose

Children 12 years and older: Most infections: Administer 250mg twice daily. Children 12 years and older: Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms: Administer 500mg twice daily. Children 12 years and older: Urinary tract infections: Administer 250mg twice daily. Children 12 years and older: Uncomplicated gonorrhea: Administer a single dose of 1g. Children 12 years and older: Lyme disease: Administer 500mg twice daily for 14 days (10~21 days). Infants and children under 12 years: Most infections: Administer 125mg twice daily. Otitis media in children 2 years and older, severe infections: Administer 250mg twice daily. Infants and children under 12 years: Lyme disease: Administer 250mg twice daily for 14 days (10~21 days). Infants under 3 months: There is insufficient experience with use.

This drug should not be administered to patients with hypersensitivity to cephalosporin-type antibiotics. Caution is advised in patients with a history of allergy to penicillin or other beta-lactam antibiotics, and in patients who frequently experience allergic symptoms such as bronchial asthma, rashes, or hives. Close monitoring is required for elderly patients with severely reduced kidney function, those unable to take oral medication or in poor nutritional status, and those with poor general health. During the administration of this drug, if unusual symptoms such as rashes, hives, itching, difficulty breathing, severe diarrhea, abdominal pain, or dizziness occur, it is important to notify the medical staff immediately and discontinue the medication. Prolonged use may lead to excessive proliferation of non-susceptible organisms such as Candida or Clostridium difficile, so therapy should be discontinued if such symptoms occur. Since this medication may affect kidney function, regular blood tests and kidney function tests are necessary; if abnormalities are found, treatment should be discontinued and appropriate measures taken. This drug can cause dizziness, so caution should be exercised when driving or operating machinery. Women who are pregnant or may become pregnant should use this drug only when the benefits outweigh the risks, and caution is required during breastfeeding as well. Safety has not been established for infants under 3 months of age, and when administering to children, it is preferable to use a dry syrup formulation to avoid the bitter taste. In elderly patients, adverse reactions may occur more easily due to decreased physiological function, thus careful observation and adjustment of dosage and administration interval are necessary. This drug may interact with other medications; caution is advised when taken concurrently with diuretics, aminoglycoside antibiotics, probenecid, antacids, etc. In case of overdose, seizures may occur, so immediate medical assistance should be sought, and drug concentration can be lowered by hemodialysis or peritoneal dialysis. Lastly, store the medication out of reach of children, and keep it sealed in its original container to maintain the quality of the drug.

• Candida overgrowth
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• granulocytopenia
• anemia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This drug should be stored in a tightly closed container to prevent exposure to air and moisture. Also, it is advisable to store it at room temperature between 1 to 30 degrees Celsius.

Appearance

White, oval, film-coated tablet

Package unit

50 tablets (10 tablets/PTP × 5)