Aclan Neo Syrup (Amoxicillin and Potassium Clavulanate)

Adult dose

There is no experience of this medication's use in adults. This medication is administered at the beginning of meals to minimize the potential for gastrointestinal disturbances. Administering this medication at the beginning of meals enhances the absorption of potassium clavulanate.

Child dose

For pediatric patients over 3 months: Based on amoxicillin content (600 mg/5 mL), take 90 mg/kg/day split into doses every 12 hours; treat acute otitis media for 10 days, and acute sinusitis for 7 days.

This medication contains the artificial sweetener aspartame, which is broken down into phenylalanine in the body. Therefore, patients with the genetic disorder phenylketonuria should not take this medication. Additionally, the daily intake of aspartame contained in this medication should be adjusted to a minimal amount not exceeding the WHO recommended level, and care should be taken not to exceed 2.4g per day for a 60kg adult. Patients with allergies to any of the components of this medication or beta-lactam antibiotics should not take it, and those with viral infections such as infectious mononucleosis or lymphocytic leukemia should also avoid this medication. Patients with a history of liver dysfunction or jaundice may experience a worsening of symptoms if this medication is taken. Since it contains lactose, patients with genetic conditions such as lactose intolerance, galactose intolerance, lactose enzyme deficiency, or glucose-galactose malabsorption should not take this medication. Patients with impaired liver or kidney function may accumulate this medication in their body; thus, dosage intervals should be adjusted or cautiously monitored. Individuals with allergic predispositions or those prone to bronchial asthma, skin rashes, or hives should exercise additional caution when taking this medication. Patients with gastrointestinal symptoms such as vomiting or diarrhea may not absorb the medication properly; therefore, caution is advised. Generally, this medication has good tolerability, but side effects such as diarrhea, vomiting, rashes, and contact dermatitis may occur. If severe diarrhea or vomiting occurs, it is advised to discontinue use and consult a physician. Gastrointestinal adverse reactions may include abdominal pain, dyspepsia, and gastritis, and rarely, severe symptoms such as pseudomembranous colitis may occur, thus requiring caution. There may also be abnormalities in liver function, particularly reported more frequently in elderly individuals or males, and liver function tests may be necessary. Severe allergic reactions or skin rashes, itching, or severe cases of skin reactions such as Stevens-Johnson syndrome may occur, so if any abnormal symptoms appear, the medication should be discontinued immediately. Hematological abnormalities such as leukopenia, thrombocytopenia, and anemia may occur rarely, hence blood tests are necessary in long-term use. Central nervous system abnormalities such as rare headaches, dizziness, or seizures may occur, and greater caution is needed for patients with decreased kidney function. This medication may interact with other drugs; therefore, particularly when used with anticoagulants, gout medications, or other antibiotics, it is essential to consult with a physician or pharmacist. Pregnant or breastfeeding women should use this medication only in special cases, as safety during pregnancy has not been established, especially during the first three months of pregnancy, it is advisable to avoid taking it. During breastfeeding, this medication may pass into breast milk, possibly causing diarrhea or skin rashes in infants; thus, caution is required. This medication should not be used in infants under three months due to the lack of confirmed safety and efficacy. While taking this medication, regular liver, kidney, and blood tests are important to monitor for abnormalities. This medication should be taken exactly as prescribed for the required duration and dosage; even if symptoms improve, it should not be discontinued arbitrarily. Before taking, shake the medication well, and after preparation, store it in a refrigerator and use it within seven days. In case of overdose, gastrointestinal symptoms, rashes, and seizures may occur, so use should be stopped immediately, and healthcare professionals consulted. Lastly, this medication should be used only for the treatment of bacterial infections and is not effective for viral infections such as colds, so unnecessary usage should be avoided.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, peeling skin, pain in oral/ocular mucosa, wheezing or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, yellowing of skin or eyes (jaundice), profound lethargy, sudden and very severe headaches, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination.

Mild side effects

• Diarrhea
• vomiting
• contact dermatitis
• hyperacidity
• abdominal pain
• stomatitis
• anorexia
• rash
• itching
• headache

This medication should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is recommended to keep it in a dry place between 1 and 25 degrees Celsius. Proper storage will help maintain the medication’s effectiveness over time.

Appearance

A syrup preparation in powder form that is white to pale yellow with a distinctive smell to be dissolved before use.

Package unit

50mL/bottle