Medication info
Lirif Capsule 75 mg (Pregabalin)

Lirif Capsule 75 mg (Pregabalin)

Prescription medicationHard capsule
Ingredient · strength
Pregabalin›75mg / 1 capsule
Manufacturer / importer
풍림무약(주)
Appearance
A hard capsule with a reddish-brown upper part and a white lower part containing white powder.
Packaging
30 capsules/bottle, 100 capsules/bottle
Approval status
Active

MFDS item code 201802164 · Approved 2018.05.24 · Insurance code 649001770

Summary

Main use
Treatment of peripheral and central neuropathic pain, adjunct for partial seizures in epilepsy, improvement of fibromyalgia.
Who uses it
Adults · Children
Adult dosage
This medication is taken orally without regard to food, divided into two doses per day with a total daily dose of pregabalin. 1. Neuropathic pain 1) Peripheral neuropathic pain An initial dose of 150 mg may be administered daily, which can be increased to 300 mg daily within 3 to 7 days. If necessary, it can be increased to a maximum of 600 mg daily at 7-day intervals. 2) Central neuropathic pain Starting dose
Children's dosage
There is insufficient safety and efficacy data for children under 12 years of age and for adolescents aged 12 to 17, so use is not recommended.

Ingredients

Manufacturer
풍림무약(주)

Efficacy & effects

Treatment of peripheral and central neuropathic pain, adjunct for partial seizures in epilepsy, improvement of fibromyalgia.

  • Peripheral and central neuropathic pain
  • partial seizures
  • fibromyalgia
View approved original text

This medication is used to treat peripheral and central neuropathic pain in adults. It is also used as an adjunct for partial seizures in epilepsy, whether accompanied by secondary generalization or not. Additionally, it is effective in the treatment of fibromyalgia. By managing various pain and seizure symptoms associated with major neurological disorders, it improves the quality of life for patients.

Dosage and Administration

Adult dosage

This medication is taken orally without regard to food, divided into two doses per day with a total daily dose of pregabalin. 1. Neuropathic pain 1) Peripheral neuropathic pain An initial dose of 150 mg may be administered daily, which can be increased to 300 mg daily within 3 to 7 days. If necessary, it can be increased to a maximum of 600 mg daily at 7-day intervals. 2) Central neuropathic pain Starting dose

Children's dosage

There is insufficient safety and efficacy data for children under 12 years of age and for adolescents aged 12 to 17, so use is not recommended.

Precautions

This medication may lead to suicidal thoughts, suicidal behavior, and symptoms of depression during use, so both patients and caregivers should closely monitor for these changes. Patients with hypersensitivity to this drug should not use it. Diabetic patients should be cautious as weight gain after taking this medication may require adjustment of antidiabetic medication doses. If swelling, particularly around the face or mouth occurs during treatment, stop taking the medication immediately and consult a healthcare professional. Elderly individuals should be particularly cautious when starting this medication as it may cause dizziness or drowsiness, increasing the risk of falls or injuries. Some patients may experience blurred vision or changes in vision after taking this medication; if any abnormal symptoms occur, inform a healthcare professional. Abruptly discontinuing this medication may cause withdrawal symptoms such as insomnia, headaches, and anxiety, so it should be gradually reduced according to a doctor's instructions. Patients with a history of drug abuse or mental illness should be closely monitored due to the risk of misuse or dependence on this medication. Patients with impaired kidney function should have their dose adjusted, and those with severe heart disease should use it cautiously. Taking this medication with opioid analgesics may increase central nervous system depressant effects, posing risks such as respiratory depression. Due to the risk of fetal malformation in early pregnancy, it is advisable for pregnant women to avoid taking this medication, and fertile women should use effective contraception. Breastfeeding women should consider discontinuing breastfeeding or the medication, as it may be transmitted through breast milk and affect the baby. Activities requiring concentration, such as driving or operating machinery, should be avoided until dizziness or drowsiness subsides after taking this medication. In cases of overdose, severe symptoms such as confusion, drowsiness, and seizures may occur, necessitating immediate medical treatment. This medication should be stored out of reach of children and should not be transferred to other containers.

Side effects and when to seek care immediately

Serious side effects

  • Hives
  • severe swelling (edema)
  • angioedema
  • facial swelling
  • chest tightness
  • difficulty breathing
  • cold sweat
  • pallor
  • severe rash with fever
  • blisters
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  • skin peeling
  • pain in oral/ocular mucosa
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • severe allergic reactions
  • severe skin adverse reactions
  • respiratory problems
  • respiratory depression
  • jaundice (yellowing of skin or eyes)
  • extreme drowsiness
  • liver abnormalities

Mild side effects

  • Dizziness
  • drowsiness
  • confusion
  • spatial disorientation
  • irritability
  • depression
  • euphoria
  • decreased libido
  • insomnia
  • depersonalization
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  • sexual dysesthesia
  • restlessness
  • anxiety
  • mood swings
  • emotional blunting
  • emotional lability
  • difficulty finding appropriate words
  • hallucinations
  • abnormal dreams
  • increased libido
  • panic attacks
  • loss of impulse control
  • apathy
  • ataxia
  • motor coordination issues
  • balance disturbances
  • amnesia
  • attention deficit
  • memory impairment
  • tremors
  • speech disturbances
  • sensory abnormalities
  • sensory reduction

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. Additionally, it is important to store it at room temperature between 15 to 30 degrees Celsius to maintain its effectiveness.

Appearance and packaging

Appearance

A hard capsule with a reddish-brown upper part and a white lower part containing white powder.

Package unit

30 capsules/bottle, 100 capsules/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.