Vysin Injection 1 Gram (Vancomycin Hydrochloride)

Adult dosage

As vancomycin, administer 500 mg (potency) intravenously every 6 hours or 1 g (potency) every 12 hours. For oral administration, take 500-2000 mg over 3-4 divided doses daily for 7-10 days, not exceeding a total daily dose of 2 g.

Children's dosage

Administer 10 mg/kg (potency) intravenously every 6 hours. Infants should receive 10-15 mg/kg (potency) every 12 hours. Infants and newborns are administerly given an initial dose of 15 mg/kg.

This medication should not be used in patients who have previously experienced severe allergic reactions or shock due to this drug. It is also safest not to administer this drug to patients who are allergic to it or to peptide- and aminoglycoside-based antibiotics. Generally, it should be avoided in patients with hearing loss or deafness, but should be used carefully if absolutely necessary. For patients with kidney function issues or acute urinary retention symptoms, this drug can accumulate in the body and cause side effects, so blood concentrations should be frequently monitored, and administration should be done carefully. Patients with liver function impairment should also be cautious as this drug can exacerbate liver function. Special care should be exercised when administering to the elderly, premature infants, newborns, and patients with damage to the vestibular or auditory apparatus. Serious allergic reactions such as shock or anaphylaxis can occur rarely when using this medication, so patients should be closely monitored, and administration should be stopped immediately if any unusual symptoms occur. Gastrointestinal issues may rarely occur, including diarrhea, nausea, vomiting, and abdominal pain. Hematological issues, such as decreased red blood cell, white blood cell, platelet counts, or increased eosinophils, can appear, so regular blood tests are advisable. In the central nervous system, dizziness, tinnitus, or hearing loss may occur, so hearing tests should be conducted to monitor the condition. Routine liver function tests should also be performed, and actions should be taken if abnormalities are found. Kidney function tests are necessary, and if issues are detected, dosage should be adjusted or stopped. Severe skin reactions such as rashes or blistering dermatitis, Stevens-Johnson syndrome can occur on the skin, so caution is warranted. Rapid infusion can lead to rash and pain on the face, neck, and torso, as well as muscle spasms, thus it should be administered slowly over a minimum of 60 minutes. Long-term use of this drug can lead to the development of resistant bacteria, so it is important to administer it only for the necessary duration. If diarrhea, abdominal pain, or fever persists after the use of antibiotics, pseudomembranous colitis should be suspected, and immediate consultation with a physician is necessary. Additionally, caution is necessary when using this medication alongside others that may affect the kidneys or nerves, as it can increase the risk of side effects. Pregnant or breastfeeding women should only use this medication when absolutely necessary, as it may affect the fetus or baby, and only under the guidance of a specialist. Newborns or premature infants should be administered carefully as their kidneys may not fully develop, which can prolong drug retention in the body. The elderly are likely to have impaired kidney function, so kidney function tests should be performed before and during administration, and dosage should be adjusted as needed. In case of overdose, severe side effects such as acute renal failure or hearing loss can occur, necessitating immediate emergency treatment. This medication must be administered intravenously, as intramuscular administration or other routes can cause tissue damage. If the infusion rate is too fast, it can cause hypotension or heart problems, so it should be administered slowly. Care should be taken when mixing with other medications due to possible chemical instability, and particularly, it should not be administered simultaneously with beta-lactam antibiotics. When using this drug, it is essential to check for discoloration or the presence of foreign substances in the injection solution to ensure safety.

Serious side effects

Shock, anaphylaxis symptoms, hives, chest tightness, difficulty breathing, cold sweat, pallor, skin peeling dermatitis, blistering dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, hypotension, wheezing, dyspnea, drug hypersensitivity syndrome (DRESS), acute generalized exanthematous pustulosis (AGEP), severe skin adverse reactions (SCAR), headache, consciousness confusion, visual disturbances, paralysis, jaundice, renal failure, severe edema, acute symptoms.

Mild side effects

• Loose stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• decreased red blood cells
• decreased white blood cells
• decreased platelets
• increased eosinophils
• dizziness

This medication should be stored in a sealed container to prevent the ingress of air, and it is best kept at room temperature between 1 to 30 degrees Celsius. This will help maintain the drug's efficacy and prevent degradation.

Appearance

The injection is a white to light yellow-brown freeze-dried powder contained in a colorless and transparent vial.

Package unit

10 vials