Ostepose Injection (Ibandronate Sodium Hydrate)

Adult administration

Administer 3mg intravenously once every 3 months over 15 - 30 seconds.

This medication must be administered intravenously, and caution is required as administration into the artery or around the vein can cause tissue damage. It must not be used in patients with a history of allergic reactions to this drug or its components, or in patients with untreated hypocalcemia. Various side effects may occur, including gastritis, diarrhea, abdominal pain, indigestion, nausea, constipation, muscle pain, joint pain, headache, and rash. Some patients may experience flu-like symptoms such as fever, chills, fatigue, arthralgia, myalgia, which are generally transient and mild to moderate in severity. Osteonecrosis of the jaw may occur during treatment, so special caution is needed for cancer patients or those receiving dental treatments. Calcium and vitamin D intake must be sufficient before administration and during treatment; hypocalcemia or bone and mineral metabolism disorders must be adequately treated. Patients with poor renal function or taking medications that may affect the kidneys require regular check-ups and monitoring. During the administration of this drug, excessive dental treatment should be avoided, and oral hygiene should be well managed. This drug can rarely cause severe side effects such as ocular inflammation, severe allergic reactions, skin rashes, atypical fractures, so any unusual symptoms should be reported to medical staff immediately. Women who are pregnant or breastfeeding are advised not to use this drug, and safety and efficacy have not been established for children under 18 years of age. In cases of overdose, renal and liver damage may occur, necessitating careful monitoring and appropriate treatment. This drug should not be mixed with calcium-containing solutions or other intravenous medications and should be administered only as an intravenous injection. After use, the syringe and needle should not be reused and must be disposed of safely.

Serious side effects

Urticaria, severe swelling (edema), angioedema, facial swelling/edema, severe allergic reactions, anaphylactic reaction/shock, Stevens-Johnson syndrome, erythema multiforme, bullous dermatitis, severe skin adverse reactions, difficulty breathing, respiratory difficulty, exacerbation of asthma, respiratory problems, liver abnormalities (jaundice), multiple organ failure, death, severe neurological symptoms, severely elevated blood pressure associated with severe edema or urinary abnormalities, acute renal failure, vascular abnormalities (thrombophlebitis

Mild side effects

• Gastritis
• diarrhea
• abdominal pain
• indigestion
• nausea
• constipation
• musculoskeletal pain
• joint pain
• muscle pain
• flu-like illness

This medication should be stored in a sealed container to prevent exposure to air, and it is safe to store at a temperature between 1 and 30 degrees Celsius. Proper storage at the correct temperature can maintain the drug's efficacy and stability.

Appearance

This injectable medication is a colorless, transparent solution contained in a colorless, transparent glass prefilled syringe with an attached single-use needle.

Package unit

3ml x 1 vial