Moxiklan Tablet 375 mg (Amoxicillin-Potassium Clavulanate)

Adult dose

Adults and children aged 12 years or older or weighing 40 kg or more should take amoxicillin/clavulanate potassium at a dosage of 250 mg/125 mg three times a day orally every 8 hours. In cases of severe and respiratory infections, the dosage may be increased to 500 mg/125 mg. For patients with renal impairment, dosage adjustments should be made according to creatinine clearance. - Creatinine clearance above 30 mL/min: No dosage adjustment required -

Child dose

For children under 12 years of age or those weighing less than 40 kg, dosage should be adjusted accordingly.

This medication is a penicillin antibiotic and should not be used in certain patients. First, patients with a history of allergy to this drug, its ingredients, or beta-lactam antibiotics may experience severe allergic reactions and should not take it. Additionally, patients with viral infections such as infectious mononucleosis or lymphocytic leukemia are at a higher risk of skin rashes while taking this medication, so it is advisable to avoid it. Patients with previous liver problems due to this medication or penicillin group drugs also pose a risk of recurrence and should refrain from taking it. Patients with impaired liver function should use this drug cautiously as it may further worsen liver function. Patients with moderate to severe renal impairment should adjust dosing intervals, as prolonged drug retention in the body may increase the risk of side effects. Patients with a history of allergies or family history, individuals who have difficulty with oral intake, the elderly, and patients in poor general condition should be cautious while taking this drug due to the risk of bleeding from vitamin K deficiency. Patients with gastrointestinal diseases or severe vomiting or diarrhea may not absorb the medication well, which necessitates caution. This drug may cause various side effects in the gastrointestinal system, with diarrhea, vomiting, abdominal pain, and appetite loss being common. Although rare, serious intestinal disorders such as pseudomembranous colitis may occur, so if diarrhea worsens or abdominal pain becomes severe, immediate discontinuation of the drug and consultation with a physician is recommended. Liver function abnormalities can also occur, with elevated liver enzymes or symptoms of jaundice, so liver function tests are necessary intermittently during treatment. Skin-related side effects such as itching or rashes, and in severe cases, serious skin reactions like Stevens-Johnson syndrome may develop, so if any unusual symptoms appear, immediate discontinuation is necessary. Blood-related side effects such as leukopenia, anemia, and thrombocytopenia have been reported rarely, making regular blood tests important. Since it may affect the central nervous system, dizziness, insomnia, seizures, etc. may occur rarely, and if any unusual symptoms arise, patients should inform their physician. It may also affect the kidneys, and symptoms such as acute renal failure or hematuria may appear, so kidney function should be monitored periodically. While taking this drug, there is a risk of fungal infections like candidiasis due to the disruption of the intestinal bacterial balance, necessitating caution. Symptoms of bleeding tendencies due to vitamin K deficiency or symptoms of vitamin B deficiencies may also occur, and conditions should be monitored. To prevent the development of resistant bacteria, it is advisable to administer this drug only for the necessary period following susceptibility testing. Patients with a history of hypersensitivity to penicillin drugs are at risk of severe allergic reactions like anaphylaxis, so an allergy history must be consulted before administration. Anaphylactic shock may occur, therefore, patients must be monitored closely after administration to ensure their stability. While using antibiotics, there is a risk of pseudomembranous colitis, so if diarrhea or abdominal cramps become severe, immediate discontinuation of the drug and consultation with a physician is essential. Long-term use may lead to proliferation of non-susceptible bacteria, thus careful monitoring is required when administered for over 14 days. Symptoms of liver dysfunction may manifest, and regular liver function tests should be conducted, especially with prolonged use beyond 14 days. As this medication is excreted through the kidneys, dose adjustments are necessary for patients with decreased renal function. Patients suspected of having infectious mononucleosis should avoid using this medication. If skin rashes or serum sickness symptoms occur, drug administration must be discontinued immediately, following the physician's instructions. In cases of long-term administration, regular examinations of kidney, liver, and hematopoietic functions should be conducted, and any abnormal signs should prompt immediate action. This drug may interact with other medications; caution is required when used in combination, particularly with anticoagulants, anti-inflammatory drugs, and certain antibiotics, and consultation with a specialist is necessary. Women who are pregnant or may become pregnant should avoid taking this medication during the first three months as a precaution, and nursing women should also be cautious as side effects may occur in the baby. It is not recommended for children under 12 years of age or those weighing less than 40 kg. Elderly patients should use this drug cautiously as they may have a higher risk of side effects due to declining physical function; hence, dosages and intervals should be carefully adjusted. This medication can affect the results of certain clinical tests, such as urine sugar tests, so these factors should be considered during evaluation. In case of overdose, gastrointestinal symptoms and renal failure, seizures, etc. may occur, so immediate cessation and suitable treatment must be provided.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mouth/eyes mucosa, shortness of breath or difficulty breathing, asthma attack, abnormalities in respiration accompanied by coughing and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, appetite loss, abdominal pain, abdominal distension, constipation, colonic pain, acid reflux, soft stools, oral dryness, candidiasis, rectal bleeding, itching, erythema multiforme, mucous membrane syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis, angioedema, serum sickness syndrome, hypersensitivity vasculitis, bronchospasm, hematological adverse reactions (leukopenia, thrombocytopenia

This medication should be stored in a closed container to prevent moisture and kept in a cool temperature between 1 to 25 degrees Celsius. Storing it this way will help maintain the drug's effectiveness for longer.

Appearance

This is a white or almost white oval film-coated tablet.

Package unit

100 tablets (10 tablets/PTPX10)