Lopam Tablet (Famciclovir)

Adult dosage

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is advisable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this drug 250 mg orally 3 times daily for 5 days. It is advisable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this drug 125 mg orally 2 times daily for 5 days. It is advisable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this drug 250 mg orally 2 times daily. Interrupt treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because the clearance of this drug decreases in patients with renal impairment, dosage adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily 10～29: 250 mg per dose, once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose, 2 times daily 10～29: 125 mg per dose, once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose, 2 times daily 10～29: 125 mg per dose, 2 times daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is advisable, taking the interval between dialysis sessions into consideration. Since 4 hours of hemodialysis reduces the plasma concentration of this drug by approximately 75%, administer this drug immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is necessary in patients with chronic compensated liver disease. Since there is insufficient treatment experience in patients with overt chronic decompensated liver disease, a clear recommended dosage has not been established.

This medication should not be used by patients who are allergic to certain ingredients. Additionally, since it contains lactose, it should not be administered to patients with lactose intolerance or specific genetic metabolic disorders. Caution is needed when using this medication in patients with impaired kidney function, and dose adjustments may be necessary. This medication may cause symptoms such as headache or nausea, but they are generally mild. Rarely, side effects such as decreased blood cell counts, hallucinations, palpitations, or skin rashes may occur, so if symptoms arise, consult a doctor immediately. This medication does not completely treat genital herpes, so it is important to avoid sexual contact when symptoms are present and to maintain safe sex practices. If symptoms such as dizziness or drowsiness occur while taking this medication, it is advised to refrain from driving or operating machinery. Patients with slightly reduced liver function do not require special dose adjustments, but patients with severe liver impairment may experience reduced efficacy. This medication does not have significant interactions with other drugs, but blood concentration changes may need to be monitored when used with some medications. Pregnant or breastfeeding women should use this medication cautiously and consult a doctor, as its safety during pregnancy has not been fully established. Use in children under 18 years is not recommended due to lack of established safety and efficacy. Elderly patients generally do not need dose adjustments, but dose adjustments should be made if kidney function is impaired. In case of overdose, hemodialysis may be helpful, and immediate treatment is required. This medication should be stored in a cool, dry place away from direct sunlight and kept out of reach of children.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucination
• palpitations

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, preferably in a dry place at temperatures below 30 degrees Celsius. Storing it this way can help maintain the effectiveness of the medication for a longer period.

Appearance

White round film-coated tablet

Package unit

21 tablets (3 PTP of 7 tablets each)