Medication info
Zeclarin 500 mg Tablet (Clarithromycin)

Zeclarin 500 mg Tablet (Clarithromycin)

Prescription medicationTablet
Ingredient · strength
Clarithromycin›500mg / 1 tablet
Manufacturer / importer
Jeil Pharmaceutical Co., Ltd.
Appearance
Yellow oval film-coated tablet
Packaging
30 tablets/bottle, 200 tablets/bottle
Approval status
Active

MFDS item code 201708639 · Approved 2017.12.29 · Insurance code 645405160

Summary

Main use
Treatment of respiratory and skin infections, mycobacterial infections, and Helicobacter pylori eradication
Who uses it
Adults · Children
Adult dosage
○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7~14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).
Children's dosage
Children aged 12 years and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

Ingredients

Manufacturer
Jeil Pharmaceutical Co., Ltd.

Efficacy & effects

Treatment of respiratory and skin infections, mycobacterial infections, and Helicobacter pylori eradication

  • Bronchitis
  • pneumonia
  • pharyngitis
  • sinusitis
  • skin and soft tissue infections
  • mycobacterial infections
  • duodenal ulcers
View approved original text

This medication is effective against various bacteria and is used to treat lower respiratory tract infections such as bronchitis and pneumonia, upper respiratory tract infections such as pharyngitis and sinusitis, as well as skin and soft tissue infections. It is also effective against infections caused by Mycobacterium avium and intracellularis, and is used to eradicate Helicobacter pylori in patients with duodenal ulcers. This helps in the treatment of various infectious diseases and contributes to the improvement of health.

Dosage and Administration

Adult dosage

○ Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7~14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).

Children's dosage

Children aged 12 years and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

Precautions

This medication should not be used in patients who are allergic to certain ingredients. Additionally, patients with abnormalities in heart rhythm or severely impaired liver and kidney function should consult their doctor before taking this medication. It is safer for pregnant or breastfeeding women to avoid this medication. This medication may interact with other drugs, so it is essential to inform your doctor or pharmacist about any current medications you are taking. If you experience any unusual symptoms such as allergic reactions, severe rashes, breathing difficulties, irregular heartbeats, severe abdominal pain, diarrhea while taking this medication, you should stop taking it immediately and consult a healthcare professional. Prolonged or high-dose use may cause hearing loss or tinnitus, so it is important to report if symptoms occur. Elderly patients or those with diminished liver or kidney function may require dose adjustments, so caution is advised. This medication should not be administered to patients with certain genetic metabolic disorders, and it is advisable to check for lactose intolerance before taking it. Caution is needed when driving or operating machinery as dizziness or confusion may occur. In case of overdose, gastrointestinal disturbances or central nervous system symptoms may occur, requiring immediate visit to a medical facility.

Side effects

  • Shock
  • anaphylactic symptoms
  • respiratory distress
  • convulsions
  • flushing
  • rash
  • itching
  • hives
  • skin flushing
  • angioedema
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  • joint swelling
  • drug rash
  • abdominal distension
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • discomfort
  • gas retention
  • diarrhea
  • oral mucosal erosion
  • upper abdominal pain
  • thirst
  • tooth discoloration
  • pancreatitis
  • increased amylase
  • taste disturbance
  • loss of appetite
  • constipation
  • stool discoloration
  • pseudomembranous colitis
  • hemorrhagic colitis
  • fever
  • cough
  • abnormal chest X-ray
  • eosinophilia
  • eosinophilic lung infiltrates
  • interstitial pneumonia
  • chronic bronchitis
  • acute maxillary sinusitis
  • eosinophilia
  • thrombocytopenia
  • pancytopenia
  • hemolytic anemia
  • leukopenia
  • agranulocytosis
  • dizziness
  • depression
  • loss of taste
  • loss of smell
  • anxiety
  • insomnia
  • nightmares
  • tinnitus
  • confusion
  • disorientation
  • hallucinations
  • psychosis
  • depersonalization
  • convulsions
  • tremors
  • numbness
  • behavioral changes
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • allergic purpura
  • drug rash
  • jaundice
  • hepatocellular hepatitis
  • cholestatic hepatitis
  • increased liver enzymes
  • liver dysfunction
  • liver failure
  • fulminant hepatitis
  • elevated AST
  • elevated ALT
  • elevated γ-GTP
  • elevated LDH
  • elevated ALP
  • increased total bilirubin
  • increased serum creatinine
  • elevated BUN
  • interstitial nephritis
  • renal failure
  • rhabdomyolysis
  • stomatitis
  • glossitis
  • oral candidiasis
  • QT prolongation
  • ventricular tachycardia
  • Torsades de pointes
  • lethargy
  • headache
  • taste disturbance
  • hearing loss
  • paresthesia
  • arthralgia
  • myalgia
  • olfactory disturbance
  • tinnitus
  • auditory impairment
  • hypoglycemia
  • tinnitus
  • hearing impairment
  • vomiting
  • nausea
  • abdominal pain
  • purpuric rash
  • acute generalized pustular rash
  • cellulitis
  • candidiasis
  • gastroenteritis
  • infection
  • vaginitis
  • leukopenia
  • neutropenia
  • thrombocytosis
  • agranulocytosis
  • thrombocytopenia
  • anaphylactic-like reaction
  • angioedema
  • decreased appetite
  • insomnia
  • nervousness
  • sound sensitivity
  • psychotic disorders
  • confusion state
  • abnormal dreams
  • musculoskeletal rigidity
  • myopathy
  • vasodilation
  • bleeding
  • asthma
  • epistaxis
  • pulmonary embolism
  • esophagitis
  • gastroesophageal reflux disease
  • gastritis
  • rectal pain
  • belching
  • bloating
  • tongue discoloration
  • tooth discoloration
  • vesicular dermatitis
  • papular rash
  • acne
  • Henoch-Schonlein purpura
  • muscle cramps
  • musculoskeletal rigidity
  • injection site phlebitis
  • injection site pain
  • injection site inflammation
  • fever
  • weakness
  • chest pain
  • chills
  • fatigue
  • abnormal albumin-globulin ratio
  • elevated serum alkaline phosphatase
  • elevated serum lactate dehydrogenase
  • increased international normalized ratio
  • prolonged prothrombin time
  • abnormal urine color

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a special container to avoid exposure to light and air, and should be kept at room temperature between 15 and 30 degrees Celsius. Storing it this way maintains the drug's effectiveness and ensures safe use.

Appearance and packaging

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.