Zekly Tablets 250 mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, or rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for a further 14 days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used by individuals allergic to certain additives or components. Those who have had hypersensitivity reactions to similar classes of antibiotics should not take this medication. Co-administration with certain heart-related medications can lead to cardiac rhythm disturbances, so concurrent use should be avoided. It is advisable to avoid this medication in patients with significant heart disease or severely impaired liver and kidney function. Pregnant or breastfeeding women should not take this medication, and breastfeeding should be discontinued while taking it. This medication may affect liver or kidney function, so caution is advised for patients with compromised organ functions. As there are many potential drug interactions, one must inform the prescribing physician about any other medications being taken, as this could lead to changes in drug concentrations or increased risk of side effects. If any sudden allergic reactions, skin rashes, or breathing difficulties occur while taking this medication, it should be discontinued immediately and medical advice sought. Gastrointestinal symptoms such as nausea, vomiting, diarrhea may occur, so caution is necessary. Long-term or high-dose use may cause tinnitus or hearing loss, and if such symptoms occur, discontinuation of the medication is advised. Elderly patients or those with cardiovascular diseases should use this medication cautiously due to potential heart-related side effects. This medication is not to be administered to patients with certain genetic metabolic disorders; prior consultation with a healthcare professional is essential. Caution should be exercised during driving or operating machinery, as dizziness or confusion may result. Exceeding the recommended dose may lead to gastrointestinal disturbances or serious neurological symptoms, so adhering to the prescribed dose is crucial. When storing this medication, it should be kept away from direct sunlight and at room temperature, ideally between 15°C to 30°C, and refrigeration should be avoided.

Shock, anaphylactic symptoms, shortness of breath, convulsions, flushing, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, loss of appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, increased LDH, elevated ALP, increased total bilirubin, loss of appetite, dark-colored urine, itching, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, parageusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, auditory impairment, purpuric rash, acute generalized pustular psoriasis, muscle cramps, musculoskeletal rigidity, myopathy, elevated serum creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is light-sensitive and should be stored in an opaque container. It is best stored at a cool room temperature between 15°C and 30°C. This storage method helps maintain the drug's effectiveness.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle