Yusetrone Injection (Palonosetron Hydrochloride)

Adult administration

1. Adults 1) Prevention of nausea and vomiting induced by cancer chemotherapy: Administer palonosetron 0.25 mg intravenously once over at least 30 seconds, 30 minutes before the start of chemotherapy. 2) Prevention of postoperative nausea and vomiting: Administer 0.075 mg intravenously once over at least 10 seconds, immediately before induction of anesthesia. As with other antiemetics, routine administration is not recommended for patients expected to have a low likelihood of postoperative nausea and vomiting. Administration of this drug is recommended for patients in whom postoperative nausea and vomiting should be avoided, even if the likelihood of postoperative nausea and vomiting is low. 3) Treatment of postoperative nausea and vomiting: Administer 0.075 mg intravenously once over at least 10 seconds as soon as nausea and vomiting occur. 3. No dose adjustment is required for elderly patients or patients with hepatic or renal impairment. There are no clinical data in patients with end-stage renal disease undergoing dialysis. This drug must not be mixed with other drugs. Flush the infusion line with normal saline before and after administration of this drug.

Child administration

2. Pediatric patients (2 months and older) 1) Prevention of acute nausea and vomiting induced by cancer chemotherapy: Administer palonosetron 0.02mg/kg (up to 1.5mg) by intravenous infusion once over at least 15 minutes, 30 minutes before the start of chemotherapy. The safety and efficacy of this drug in neonates have not been established (no data are available). Data on the use of this drug to prevent nausea and vomiting induced by cancer chemotherapy in infants (under 24 months) are limited.

This medication should not be given to patients who are allergic to this medication or its components. Patients who have shown allergic reactions to similar class medications should exercise caution, as they may react to this medication as well. This medication can slow bowel movements; therefore, patients with constipation or signs of intestinal obstruction should be closely monitored. Patients taking other serotonin-related medications should be carefully monitored according to their physician's instructions, as they may experience side effects similar to serotonin syndrome. This medication is used to prevent or treat nausea and vomiting, and may cause side effects such as headaches, constipation, diarrhea, dizziness, and fatigue. Cardiovascular symptoms such as irregular heartbeat or changes in blood pressure have been reported, though most have no clear direct relation to this medication. While animal studies did not reveal significant issues during pregnancy, adequate research in pregnant women is lacking, thus it should be used only when absolutely necessary. For breastfeeding mothers, careful consideration should be given to whether to continue or discontinue breastfeeding, as this medication may be transferred to breast milk. Dizziness, drowsiness, and fatigue may occur, requiring caution when driving or operating machinery. In the case of overdose, there is no specific antidote, and supportive treatment according to symptoms is required; dialysis is not effective. This medication should be stored away from direct sunlight and at room temperature, and it should be checked for discoloration or foreign substances before administration. Elderly patients can use this medication at similar doses as general adults, but should be closely monitored for sensitive reactions.

• Headache
• constipation
• diarrhea
• dizziness
• fatigue
• abdominal pain
• insomnia
• non-persistent tachycardia
• bradycardia
• hypotension

This medication should be stored at room temperature between 1°C and 30°C in a sealed container that does not allow air to enter. It is also important to store it in a dark place to avoid exposure to light.

Appearance

A colorless and transparent liquid contained in a colorless and transparent prefilled syringe

Package unit

1.5mL x 5 prefilled syringes, 5mL x 1 prefilled syringe