Povierd Tablet (Tenofovir Disoproxil Fumarate)

Adult dose

For the treatment of adult HIV-1 infection or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. For patients with a baseline creatinine clearance of <50mL/min, adjust the dosing interval of this medicine according to Table 1. No adjustment to the dosing interval is necessary for patients with mild renal impairment (creatinine clearance 50-80mL/min) Creatinine clearance (mL/min)a ≥50: every 24 hours Creatinine clearance (mL/min)a 30-49: every 48 hours Creatinine clearance (mL/min)a 10-29: every 72-96 hours Patients on hemodialysis: every 7 days or after a total of approximately 12 hours of dialysisb The pharmacokinetics of tenofovir have not been evaluated in patients with a creatinine clearance of less than 10mL/min who are not receiving hemodialysis; therefore, no dosing recommendations are available for these patients.

Child dose

For pediatric patients aged 12 years and older (weighing at least 35kg) with HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The safety and efficacy of this medicine have not been established in pediatric patients with chronic hepatitis B who weigh less than 35kg.

This medication is an antiviral agent used for the treatment of hepatitis B virus (HBV) infection. Discontinuing treatment may lead to a sudden worsening of hepatitis, so regular monitoring should occur for several months after stopping the medication. Individuals allergic to this medication or its components should not take it. Patients with lactose intolerance or certain genetic metabolic disorders should also avoid this medication. This medication should not be taken in combination with other tenofovir products or adefovir dipivoxil. Patients with impaired kidney function should undergo regular monitoring of renal function, as this medication is excreted through the kidneys, and dosage intervals should be adjusted if necessary. Particularly, patients taking high doses of non-steroidal anti-inflammatory drugs (NSAIDs) should be cautious due to the risk of renal damage. It may affect bone health, and patients at risk for osteoporosis or fractures should consider bone density testing, and calcium and vitamin D supplements may be beneficial. This medication contains Yellow No. 5 colorant, so patients allergic to this component should exercise caution. Common side effects may include headache, diarrhea, nausea, fatigue, and rash; if severe adverse reactions occur, medical personnel should be consulted immediately. Insufficient safety data is available during pregnancy, so it should only be used when absolutely necessary, and breastfeeding mothers are advised to avoid breastfeeding. Safety and efficacy have not been established for children under 12 years of age or who weigh less than 35 kg. Caution is needed when administering to elderly patients aged 65 years and older, considering renal and liver function. In case of overdose, seek immediate medical attention, and some drugs may be removed by dialysis. Store this medication at room temperature away from children, ensuring it is kept in its original container to maintain quality.

• Worsening of hepatitis
• acute renal failure
• Fanconi syndrome
• hypophosphatemia
• renal impairment
• bone pain
• limb pain
• fractures
• muscle pain
• muscle weakness

This medication should be stored in a tightly closed container to protect it from exposure to air or moisture, and it is safe to store at room temperatures between 1 degree and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a longer period.

Appearance

Pale blue almond-shaped film-coated tablet

Package unit

30 tablets/bottle