Cravix 500mg (Clarithromycin)

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily; for severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. For patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this product twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this product 3 times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. In other words, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years and older: Same as adults. For children under 12 years, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, patients who are allergic to any of the ingredients in this medication or similar classes of antibiotics should not be administered the drug. Precautions are also necessary for patients taking medications that may cause cardiac arrhythmias or those with a history of heart disease. It is also safest for patients with severe liver or kidney damage, and for women who are pregnant or breastfeeding to avoid this medication. As this drug contains lactose, it should not be administered to patients with lactose intolerance or related genetic disorders. This medication should be used with caution in patients with liver and kidney function impairment, elderly patients, and those taking other antibiotics. In particular, patients with a history of drug allergies need to be more careful. Patients who are allergic to the dyes present in this drug should also be cautious. Rarely, while taking this medication, serious allergic reactions or skin adverse reactions, gastrointestinal disturbances, liver dysfunction, kidney problems, central nervous system abnormalities, or hearing issues may occur. If these symptoms appear, discontinue the medication immediately and consult medical personnel. Long-term or high-dose use of this medication may lead to symptoms such as tinnitus or hearing loss, so caution is required. It may also impact the results of certain tests, so it is advisable to inform healthcare providers before testing. This medication has a high potential for interactions with other drugs, so if you are taking any other medications, you must inform medical personnel. Caution is particularly necessary when combined with cardiac-related medications, anticoagulants, steroids, blood sugar-lowering agents, and certain antiviral drugs. It is safest for pregnant or breastfeeding women to avoid this medication, and if it must be used, breastfeeding should be discontinued. When prescribing this medication to children or the elderly, dosage adjustments and close monitoring of conditions should be carried out, particularly for elderly patients with impaired kidney function. In case of overdose, gastrointestinal disturbances or mental alteration symptoms may appear, so contact medical personnel immediately for appropriate treatment. This medication should not be refrigerated during storage; it is best to keep it in a tightly sealed container, away from direct sunlight, and at room temperature.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, pruritus, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, chest X-ray abnormalities, increased eosinophils, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste alteration, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular psoriasis, muscle cramps, musculoskeletal stiffness, myopathy, elevated blood urea, venous thrombophlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication should be stored in a tightly sealed container that is not exposed to light, preferably at room temperature between 15 to 30 degrees Celsius. Proper storage can help maintain the efficacy of the medication for a longer time.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle