Palisper 6 mg (Paliperidone)

Adult dose

Adults (18 years and older) This medicine is administered orally as paliperidone 6mg once daily in the morning. Administration of this medicine with food or on an empty stomach should be consistent and should not be switched. No initial dose adjustment is required. Some patients may benefit from a lower or higher dose within the dose range of 3-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If a dose increase is needed, it is recommended to increase the dose by 3mg per day at intervals of at least 5 days. Schizoaffective disorder - Adults (18 years and older) This medicine is administered orally as paliperidone 6mg once daily in the morning. Administration of this medicine with food or on an empty stomach should be consistent and should not be switched. No initial dose adjustment is required. Some patients may benefit from a lower or higher dose within the dose range of 3-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If a dose increase is needed, it is recommended to increase the dose by 3mg per day at intervals of at least 4 days. This medicine should be swallowed whole with liquid and should not be chewed, cut, or crushed. The medicine is contained within a nonabsorbable membrane designed to release the medicine at a controlled rate. The tablet-shaped membrane, together with insoluble core components, is excreted from the body. There is no need for concern if tablet-shaped material is found in the stool. No dose adjustment is required in patients with mild or moderate hepatic impairment (Child-Pugh Classification A and B). This medicine has not been studied in patients with severe hepatic impairment. Dosing should be individualized according to the patient's renal function. Patients with mild renal impairment (creatinine clearance 50ml/min or more and less than 80ml/min): The recommended initial dose is 3mg once daily. Following clinical reassessment, the dose may be increased to a maximum of 6mg per day. Patients with moderate or severe renal impairment (creatinine clearance 10ml/min or more and less than 50ml/min): The recommended initial dose is 1.5mg once daily. Following clinical reassessment, the dose may be increased to a maximum of 3mg per day. This medicine has not been studied in patients with creatinine clearance less than 10ml/min; therefore, administration of this medicine to these patients is not recommended. Renal function may be decreased in elderly patients, so dose adjustment may be necessary according to renal function. In general, the recommended dose for elderly patients with normal renal function is the same as that for adults with normal renal function. In patients with moderate or severe renal impairment (creatinine clearance 10ml/min or more and less than 50ml/min), the maximum recommended dose of this medicine is 3mg once daily (see the 'Patients with renal impairment' section under Dosage and Administration).

Child dose

Adolescents (12 years to 17 years): This medication should be administered orally as paliperidone 3mg once daily in the morning. Administer this medication consistently either with food or on an empty stomach; do not alternate between the two. No initial dose adjustment is necessary. Some patients may benefit from higher doses within the range of 6-12mg of paliperidone once daily. Dose adjustments should be made only after clinical reassessment. If a dose increase is needed, increase by 3mg per day at intervals of at least 5 days. Less than 51kg: 6mg 51kg or more: 12mg

This medication may increase mortality when used in elderly patients with dementia-related psychosis, so caution is advised. Risk factors for venous thromboembolism should be assessed and preventive measures should be taken before using this medication. It should not be administered to patients with known allergies to this medication or its components, patients with severe gastrointestinal obstruction or dysphagia, nursing mothers, or patients with certain hereditary diseases. It should be used with caution in patients with certain conditions such as cardiovascular disease, epilepsy, renal impairment, and diabetes. This medication can cause various side effects such as arrhythmias, gastrointestinal problems, neurological symptoms, and psychiatric symptoms, therefore monitoring is necessary. It may cause QT interval prolongation; therefore, it should not be used with related medications or in patients with congenital long QT syndrome. Monitoring is required due to the potential for severe side effects such as neuroleptic malignant syndrome, tardive dyskinesia, hyperglycemia, weight gain, orthostatic hypotension, and seizure risk. During pregnancy, its safety has not been established, and it should only be used when the benefits outweigh the risks. Nursing mothers should not take this medication. For children under 12 years of age, safety and efficacy have not been established. In case of overdose, immediate consultation with a healthcare provider and appropriate emergency treatment are necessary. Caution is needed when driving or operating machinery, and side effects may increase when used with other central nervous system medications or alcohol. There may be potential drug interactions, so be sure to confirm the relationship with other medications being taken. This medication should be kept out of reach of children and stored away from moisture and direct sunlight.

increased mortality, heart failure, sudden death, pneumonia, venous thromboembolism, first-degree atrioventricular block, bradycardia, bundle branch block, palpitations, cardiac arrhythmia, tachycardia, rapid heartbeat, dry eyes, eye movement, blurred vision, abdominal pain, upper abdominal pain, diarrhea, dry mouth, dyspepsia, nausea, hypersalivation, gastric discomfort, toothache, vomiting, weakness, fatigue, fever, bronchitis, nasopharyngitis, rhinitis, upper respiratory tract infection, viral infection, falls, increased alanine aminotransferase, increased creatine phosphokinase in the blood, increased insulin in the blood, increased blood pressure, increased serum triglycerides, prolonged QT interval on ECG, abnormal T wave on ECG, T wave inversion on ECG, abnormal ECG, increased heart rate, increased C-peptide insulin, weight loss, weight gain, decreased appetite, increased appetite, joint pain, low back pain, muscle stiffness, neck pain, severe pain, shoulder pain, inability to sit cross-legged, dizziness, movement disorders, muscle tone disorders, extrapyramidal disorder, headache, excessive tension, Parkinsonism, sedation, drowsiness, syncope, tremors, aggression, anxiety, depression, nightmares, suicidal thoughts, cough, nasal congestion, itching, hypotension, orthostatic hypotension, tongue swelling, oral ulcers, edema, anaphylactic reaction, grand mal seizures, hypersomnia, nightmares, amenorrhea, breast discharge, mastitis, breast pain, erectile dysfunction, excessive milk secretion, gynecomastia, menstrual irregularity, ischemia, atrial fibrillation, deep vein thrombosis, pulmonary embolism, sleep apnea syndrome, pancreatitis, intestinal obstruction, jaundice, angioedema, hair loss, DRESS syndrome, urinary retention, urinary incontinence, neonatal drug withdrawal symptoms, priapism, hypothermia, tension syndrome, mania, sleepwalking, taste abnormalities, delayed movement disorders, sleep-related eating disorders, intraoperative iris hypotension syndrome, hyperglycemia, diabetes, diabetic ketoacidosis, hypoglycemia, water intoxication, amnesia, worsening of depression, impaired concentration, dysphagia, gastroesophageal reflux, hyperlipidemia, frequent urination, erectile dysfunction, facial edema, chest tightness, gastric ulcer, sensory abnormalities, intentional tremor, joint stiffness, suicide attempt, psychomotor agitation, runny nose, dysphagia, facial edema, chest tightness, death, pain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and should be kept in a cool place between 15 and 30 degrees Celsius. Avoid storing in humid places, as moisture can reduce the effectiveness of the medication.

Appearance

Pale yellow circular sustained-release film-coated tablets

Package unit

30 tablets/bottle