Ilseong Ceftriaxone Injection 1 Gram (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children over 12 years: Administer 1-2g (potency) of ceftriaxone once daily by intravenous or intramuscular injection. For infections caused by severe illness or moderate-susceptible pathogens, the dosage may be increased to a maximum of 4g (potency) once daily. For gonorrhea treatment: A single dose of 250mg (potency) is recommended as an intramuscular injection. Post-operative infection

Child administration

Neonates (within 14 days of birth): Administer 20-50mg (potency) per kg of body weight once daily, not exceeding 50mg (potency). Infants and children (from 15 days to 12 years): Administer 20-80mg (potency) per kg of body weight once daily. For children over 50kg, adult dosage should be administered.

This medication must not be mixed with solutions containing calcium or other drugs when administered together. In particular, it should never be administered with calcium to newborns, as precipitate can form and lead to serious side effects. Patients who are hypersensitive to this medication or have allergies to cephalosporins, penicillins, and certain local anesthetics such as lidocaine should not be given this drug. Premature infants or newborns with bilirubin binding issues should also not use this medication. Patients with a history of drug allergies or allergic constitution should use it with caution, and those with severely impaired kidney function may require dosage adjustment. Furthermore, it poses a risk of vitamin K deficiency, so blood coagulation status must be checked periodically. This medication may cause side effects such as eosinophilia, leukopenia, thrombocytopenia, diarrhea, rashes, liver function abnormalities, dizziness, bronchospasm, loose stools, nausea, vomiting, itching, hematuria, diabetes, thrombophlebitis, injection site pain, fever, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B deficiency, edema, ventricular extrasystoles, sweating, flushing, palpitations, nosebleeds, Clostridium difficile diarrhea, hypotension, and pancreatitis. Serious allergic reactions, skin reactions, renal dysfunction, or neurological issues may appear rarely, and if symptoms occur, consult a physician immediately. When administering this medication, sensitivity tests should be conducted to prevent the development of resistant strains, and it should be used for the duration necessary. During administration, regular monitoring of liver and kidney functions and blood tests are advised. Use in pregnant or nursing women must be carefully considered; particularly, use should be avoided in newborns and premature infants due to the risk of bilirubin encephalopathy. In elderly patients, the likelihood of side effects may be higher due to decreased bodily function, so dosing should be cautious. This medication may interact with other medications; caution is necessary, especially when used in conjunction with diuretics, aminoglycoside antibiotics, anticoagulants like vitamin K antagonists, and the patient’s renal function and bleeding risks should be closely monitored. Injection may cause pain or inflammation at the site of injection, and the injection should be administered slowly. Prepared solutions should be used as quickly as possible, and the appropriate temperature should be maintained during storage. Caution is needed while driving or operating machinery, as symptoms like dizziness may occur. In the case of overdose, there are no specific antidotes, and treatment must be symptomatic.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/eye mucosal pain, shortness of breath or difficulty breathing, asthma attack, abnormal breathing accompanied by cough + fever, yellowing of the skin or eyes (jaundice), extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination changes

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• dizziness
• bronchospasm
• loose stools
• nausea

This medication should be stored in a sealed container to prevent exposure to air and moisture, and should be kept at room temperature between 1 to 30 degrees Celsius to maintain its effectiveness and safety.

Appearance

A colorless, transparent vial filled with white to light yellow crystalline powder

Package unit

1g/vial X 10 vials/box