Crosstein 20 mg (Rosuvastatin Calcium)

Adult dosage

The initial dose is 5 mg once daily, and if a greater reduction in LDL cholesterol is needed, it can be adjusted to the maintenance dose. The maintenance dose is usually 10 mg once daily for most patients. The maintenance dose should be appropriately adjusted based on LDL cholesterol levels, treatment goals, and patient response, with a maximum daily increase of 20 mg.

Children's dosage

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17 years) is 5 mg to 20 mg once daily. The recommended dosage should be adjusted based on individual patient therapeutic goals.

This medication should not be used in certain patients. For instance, patients with allergies to this medication's ingredients, severe liver dysfunction, muscle disorders, as well as pregnant or breastfeeding women should not take this medication. Patients with severely impaired kidney function or those taking certain medications also need to be cautious. Notably, patients at high risk for muscle-related side effects should not take the 40 mg dose of this medication. It is important to regularly check liver function and muscle condition before and while taking this medication. If symptoms such as muscle pain or weakness occur, immediate consultation with a physician is necessary. Patients who consume large amounts of alcohol or have a history of liver disease should also exercise caution while taking this medication, and those with hypothyroidism or nephrotic syndrome should use this medication only after treating the underlying causes. This medication contains lactose and is unsuitable for patients with lactose intolerance. This medication may interact with other drugs, so it is crucial to inform your physician or pharmacist if you are taking other medications. Particularly, the risk of muscle side effects may increase when combined with certain antiviral agents, immunosuppressants, antifungals, and antibiotics. Women of childbearing potential should use appropriate contraception before taking this medication and should not take it during pregnancy. Adverse reactions during use may include headache, dizziness, muscle pain, gastrointestinal disturbances, and in rare cases, severe liver damage or muscle rupture. In cases of overdose, there is no specific antidote, and treatment should be symptomatic and include liver and muscle function tests. Patients should be aware that dizziness may occur while driving or operating machinery. This medication may have higher plasma concentrations in Asians, necessitating dose adjustments. All these considerations must be followed for safe and effective treatment, and it is important to adequately consult with healthcare professionals before and during use.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), severe allergic reactions, jaundice, liver abnormalities (jaundice), acute renal failure, thrombocytopenia, severe skin adverse reactions, severe neurological symptoms, severe edema or urination abnormalities, severe muscle weakness, rhabdomyolysis, immune-mediated necrotizing myopathy, respiratory issues.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• muscle pain
• weakness
• cough

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature of 1 to 30 degrees Celsius in a cool, dry place. This will help preserve the medication's effectiveness for a longer period.

Appearance

Pink round film-coated tablet

Package unit

28 tablets (14 tablets/PTP*2), 30 tablets/bottle, 100 tablets/bottle