Purloxacin 250 mg (Cefuroxime Axetil)

Adult dose

For optimal absorption, this drug should be taken after meals. 3. Patients with renal impairment Cefuroxime is excreted primarily by the kidneys. In patients with significantly impaired renal function, dose reduction of cefuroxime as shown below is recommended to compensate for delayed excretion. Creatinine clearance / T1/2 (hours) / Recommended dosage ≥ 30 mL/min/1.73 ㎡ / 1.4 - 2.4 / No dosage adjustment necessary (Standard dosage: 125 mg - 500 mg twice daily) 10 - 29 mL/min/1.73 ㎡ / 4.6 / Administer the standard single dose every 24 hours < 10 mL/min/1.73 ㎡ / 16.8 / Administer the standard single dose every 48 hours Patients undergoing hemodialysis / 2 - 4 / Administer an additional standard single dose at the end of each dialysis session For the treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this drug should be administered for 7~10 days. This drug must not be divided and is therefore not suitable for patients who cannot swallow tablets, such as young infants and children.

Child dose

Adults and adolescents aged 12 years and older: Most infections — Administer 250mg twice daily. Adults and adolescents aged 12 years and older: Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by organisms with reduced susceptibility — Administer 500mg twice daily. Adults and adolescents aged 12 years and older: Urinary tract infections — Administer 250mg twice daily. Adults and adolescents aged 12 years and older: Uncomplicated gonorrhea — Administer a single dose of 1g. Adults and adolescents aged 12 years and older: Lyme disease — Administer 500mg twice daily for 14 days (10~21 days). Infants and children under 12 years of age: Most infections — Administer 125mg twice daily. Otitis media in children aged 2 years and older, severe infections: Administer 250mg twice daily. Infants and children under 12 years of age: Lyme disease — Administer 250mg twice daily for 14 days (10~21 days). There is insufficient experience with use in infants under 3 months of age.

This medication should not be used in patients with hypersensitivity to cephalosporin antibiotics. It should be administered with caution to patients with a history of allergy to penicillins or other beta-lactam antibiotics, or if they have a tendency to frequently experience allergy symptoms such as bronchial asthma, rash, and urticaria in themselves or among family members. Special caution is required for patients with severely impaired kidney function, those who have difficulty swallowing, elderly patients, or those in poor general health, and adequate monitoring for signs of vitamin K deficiency is essential. While using this medication, it is possible for mild symptoms to progress to severe skin rashes, urticaria, or anaphylaxis, so medical personnel should be notified immediately if symptoms occur. Gastrointestinal or neurological symptoms such as headache, dizziness, diarrhea, nausea, and abdominal pain may occur, and elderly patients or those with severe infections may also experience symptoms like confusion or hallucinations. Regular monitoring and tests are necessary as this medication may affect liver and kidney function; if any adverse symptoms are detected, the medication should be discontinued immediately and appropriate treatment should be provided. Prolonged use of antibiotics may lead to excessive overgrowth of Candida or other non-susceptible bacteria, so caution is needed for long-term use. If diarrhea or abdominal pain worsens, consider the possibility of pseudomembranous colitis and consult medical personnel immediately. This medication may cause dizziness, so caution is advised when driving or operating machinery. Women who are pregnant or may become pregnant should use this drug only when the benefits outweigh the risks, and caution is also needed during breastfeeding. Safety has not been established in infants under 3 months of age, and for children, it is recommended to use a dry syrup formulation due to the bitter taste. Elderly patients are at higher risk for adverse reactions due to diminished physiological functions, so dosage and administration intervals should be adjusted and observed carefully. This medication may affect certain clinical test results, so it is important to inform medical personnel of its use during tests. In case of overdose, central nervous system side effects such as seizures may occur, so caution is needed, and drug levels can be reduced through hemodialysis or peritoneal dialysis. Finally, keep this medication out of the reach of children, and store it in its original container to prevent misuse or degradation of quality.

• Candidiasis hyperproliferation
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• neutropenia
• anemia
• hemoglobin decrease
• hematocrit decrease
• hemolytic anemia

This medication should be stored in an airtight, sealed container at room temperature between 1 and 30 degrees Celsius. This helps maintain the drug's effectiveness and prevent degradation.

Appearance

White, rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTP x 5)