Tenofovir Tablets (Tenofovir Disoproxil Fumarate)

Adult dose

Adults For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. Patients with renal impairment For patients with a baseline creatinine clearance of <50mL/min, adjust the dosing interval of this medicine according to Table 1. No adjustment to the dosing interval is needed in patients with mild renal impairment (creatinine clearance 50-80mL/min). Table 1. Adjustment of dosing interval according to creatinine clearance Creatinine clearance (mL/min)a: ≥50 — Recommended interval for 300mg dose: every 24 hours Creatinine clearance (mL/min)a: 30-49 — Recommended interval for 300mg dose: every 48 hours Creatinine clearance (mL/min)a: 10-29 — Recommended interval for 300mg dose: every 72-96 hours Patients on hemodialysis — Recommended interval for 300mg dose: every 7 days or approximately 12 hours after dialysisb a. Calculated using ideal (lean) body weight. b. Assuming 3 hemodialysis sessions of approximately 4 hours each per week, administer once weekly. This medicine should be administered after dialysis is completed. The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance less than 10mL/min who are not receiving hemodialysis; therefore, no dosing guidelines are available for these patients.

Child dose

Children aged 12 years and older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. Pediatric patients with chronic hepatitis B weighing less than 35kg: Safety and efficacy have not been established. Pediatric patients with renal impairment: No data are available to support dose recommendations.

This medication is used for the treatment of hepatitis B virus infection. Sudden discontinuation of this medication during treatment can lead to a rapid worsening of hepatitis; therefore, long-term medical observation is necessary even after discontinuation. Individuals who are allergic to any ingredient in this medication or have specific genetic metabolic disorders like lactose intolerance should not take this medication. Moreover, this medication must not be used in conjunction with other drugs that contain the same active ingredient or with certain specific medications, so it is essential to consult with healthcare providers. Patients with reduced kidney function may experience additional burden on their kidneys from this medication; thus, regular kidney function tests should be performed prior to and during treatment, and the dosing interval should be adjusted as needed. This medication can cause bone-related side effects, such as decreased bone density or osteomalacia in some patients, so those with bone health issues or risk factors should consider bone density testing. While taking this medication, side effects such as headache, diarrhea, nausea, fatigue, rash, and others may occur; if these symptoms are severe or persistent, medical advice should be sought. Pregnant women may use this medication as there is sufficient safety data regarding the fetus, but it should always be used according to a doctor’s instructions. Breastfeeding mothers are advised to avoid this medication as it may be excreted in breast milk and affect the baby. This medication should generally not be used in children under 12 years of age or weighing less than 35 kg due to insufficient evidence of safety and efficacy. Special attention should be given when administering this medication to elderly patients with reduced kidney function, and it's essential to inform healthcare providers about any concurrent medications due to potential interactions. In case of overdose, appropriate treatment should be initiated, and the patient's condition should be closely monitored, as the medication can be removed by hemodialysis. This medication must be stored at room temperature and kept out of reach of children, ideally in its original container.

• Worsening of hepatitis
• hypersensitivity
• acute renal failure
• Fanconi syndrome
• hypophosphatemia
• kidney dysfunction
• bone pain
• limb pain
• fractures
• muscle pain

This medication should be stored in a tightly closed container to prevent exposure to air, and it is best kept at room temperature between 1 to 30 degrees Celsius. Storing it this way will help maintain its effectiveness.

Appearance

Light blue almond-shaped film-coated tablets

Package unit

30 tablets/bottle