Lamprim Soft Capsule 100 mg (Clofazimine)

Adult dose

1. Lepromatous and borderline leprosy Administer clofazimine 100 mg per dose 3 times a week. 2. Lepromatous and borderline leprosy resistant to dapsone Administer this medicine 100 mg daily for long-term treatment together with rifampicin 600 mg. 3. Leprosy reactions, such as erythema nodosum leprosum Administer this medicine 300 mg once daily, usually for 3 months. If a leprosy reaction occurs during treatment, immediately reduce the dose gradually to a level that adequately maintains suppression of the reaction. A daily dose of 300 mg or more should not be administered for 3 months or longer. In principle, administer in combination with other antileprosy drugs. Take with food or milk. Adjust the dose appropriately according to body weight and the severity of disease progression.

This medication should not be used in patients with an allergy to this drug or any of its components. Patients allergic to soybean oil, soy, peanuts, etc., should also avoid taking this medication. Patients with gastrointestinal disorders or those at risk of aggravation should use this medication cautiously. Patients with kidney or liver function issues should also take this medication with caution. Women who are pregnant or may become pregnant and those who are breastfeeding should exercise caution when using this medication. Patients with lipid metabolism disorders or those who require caution with lipid emulsions should consult a physician before taking this medication. This medication may cause skin-related adverse reactions such as skin pigmentation and hair discoloration, and symptoms may worsen with sun exposure. Gastrointestinal symptoms may include nausea, vomiting, abdominal pain, diarrhea, and constipation. Caution should be exercised as symptoms such as eye discoloration, dryness, and vision impairment may occur. Neurological symptoms such as dizziness, headache, and drowsiness have also been reported. Regular check-ups are necessary as hepatic function abnormalities or blood-related adverse reactions may arise. Long-term high-dose use of this medication may rarely lead to intestinal obstruction or splenic infarction; if abdominal pain or diarrhea occurs, consult a physician immediately. If diarrhea or vomiting is severe, hospitalization may be necessary. For long-term use, it is advisable to undergo liver and kidney function tests every three months. Depression due to skin pigmentation may occur; thus, careful observation of changes in mental state is required. Risky activities such as driving or operating machinery should be avoided when experiencing drowsiness or diminished vision symptoms. Patients with a risk of lipid overload should regularly check their blood lipid levels, and dosage adjustments may be necessary. This medication may increase the risk of specific arrhythmias; therefore, cardiac status should be monitored through electrocardiograms. There may be interactions when used with other medications, so it is imperative to inform the physician about any other medications being taken. In pregnancy or lactation, careful use is advised due to potential effects on the fetus or infant, such as skin discoloration. Elderly patients may have diminished body function and should be careful regarding the occurrence of adverse reactions while using this medication. In case of overdose, specific antidotes are not available, and emergency measures such as inducing vomiting or gastric lavage may be necessary. This medication should be kept out of the reach of children and stored at room temperature away from direct sunlight and moisture.

• Skin depigmentation
• skin pigmentation
• hair depigmentation
• skin dryness
• scaling
• itching
• photosensitivity reaction
• rash
• erythema
• nausea

This medication should be stored in a tightly sealed container that allows for good ventilation and kept in a cool place where the temperature is below 30 degrees Celsius while avoiding moisture. By doing so, the effectiveness of the medication can be maintained for a longer period.

Appearance

Brown oval soft capsule containing a dark reddish-brown to brown content

Package unit

100 capsules/bottle, 30 capsules/bottle