Tenofovir Disoproxil Fumarate Tablet

Adult dose

Adults: For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. For patients with baseline creatinine clearance <50mL/min, adjust the dosing interval for this medicine with reference to Table 1. Creatinine clearance 50-80mL/min: No adjustment to the dosing interval for this medicine is necessary. Creatinine clearance (mL/min) ≥50: Recommended 300mg dosing interval: every 24 hours Creatinine clearance (mL/min) 30-49: Recommended 300mg dosing interval: every 48 hours Creatinine clearance (mL/min) 10-29: Recommended 300mg dosing interval: every 72-96 hours Patients on hemodialysis: Recommended 300mg dosing interval: every 7 days or approximately 12 hours after completion of dialysis In general, administer once weekly, assuming 3 hemodialysis sessions of approximately 4 hours each per week. This medicine should be administered after dialysis is completed. The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance below 10mL/min who are not receiving hemodialysis; therefore, no dosing recommendations are available for these patients.

Child dose

Pediatric patients aged 12 years or older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. Pediatric patients weighing less than 35kg with chronic hepatitis B: Safety and efficacy have not been established. Pediatric patients with renal impairment: There are no data to support a dose recommendation.

This medication is an antiviral agent used for the treatment of chronic hepatitis B and HIV-1 infection. Abruptly stopping this medication can lead to a rapid deterioration of hepatitis, so continued monitoring is necessary for several months after therapy ceases. Patients with a history of allergy to this medication or specific genetic disorders such as lactose intolerance should not take it. Additionally, this medication should not be taken with other drugs containing tenofovir or adefovir. Patients with impaired or worsening kidney function should have their kidney function monitored regularly before and during the use of this medication, and dosing intervals should be adjusted based on kidney function. It is advisable to avoid taking it with nonsteroidal anti-inflammatory drugs (NSAIDs), which can place additional burden on the kidneys. This medication may have side effects associated with reduced bone density; thus, patients with a risk of fractures or osteoporosis should consider bone density testing. If pain in the bones or muscles persists during treatment, consult a doctor immediately. This medication can cause various side effects; common symptoms include headache, diarrhea, nausea, rash, and depression. It is relatively safe to use during pregnancy; however, it must be used under the direction of a physician during pregnancy. Breastfeeding mothers are advised to avoid breastfeeding while taking this medication. The safety and efficacy have not been established for children under 12 years or those weighing less than 35 kg. Caution is required for elderly patients over 65 years due to the potential for liver and kidney function decline. In the event of an overdose, seek immediate medical care for appropriate treatment and monitoring, as this medication can be removed by hemodialysis. Store this medication at room temperature away from direct sunlight and ensure it is kept out of reach of children.

• Worsening of hepatitis
• hypersensitivity
• acute renal failure
• Fanconi syndrome
• hypophosphatemia
• bone pain
• limb pain
• fractures
• muscle pain
• tubular myopathy

This medication may be sensitive to air and moisture, thus should be stored in a tightly sealed container. It is recommended to maintain storage temperatures between 1 and 30 degrees Celsius. Proper storage will help retain the medication's efficacy for a longer period.

Appearance

Light blue almond-shaped film-coated tablets

Package unit

30 tablets/bottle