Tenorid Tablets (Tenofovir Disoproxil)

Adult dose

Adults: For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet once daily (equivalent to 245mg of tenofovir disoproxil). It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. For patients with a baseline creatinine clearance of <50mL/min, adjust the dosing interval of this medicine with reference to Table 1. In patients with mild renal impairment, no dose interval adjustment is necessary (creatinine clearance 50-80mL/min). Regularly monitor the estimated creatinine clearance and serum phosphate (see Warning 3). Table 1. Dose interval adjustment based on creatinine clearance Creatinine clearance (mL/min)a ≥50: 1 tablet every 24 hours 30-49: 1 tablet every 48 hours 10-29: 1 tablet every 72-96 hours Patients on hemodialysis: 1 tablet every 7 days or approximately 12 hours after hemodialysisb b. Assuming 3 hemodialysis sessions per week, each lasting approximately 4 hours, administer once weekly. This medicine should be administered after hemodialysis is completed. The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance <10mL/min who are not receiving hemodialysis; therefore, no dosage recommendations are available for these patients.

Child dose

Pediatric patients aged 12 years and older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet once daily (equivalent to 245mg of tenofovir disoproxil). It may be taken with or without food. Pediatric patients with chronic hepatitis B who weigh less than 35kg: Safety and efficacy have not been established.

This medication can severely worsen hepatitis upon discontinuation, so it is essential to monitor liver function closely for an extended period after stopping treatment. Patients with allergies to any of the ingredients in this medication or those with specific hereditary lactose intolerance should not use it. It should not be taken with other drugs that have similar components or certain specific drugs, especially for patients with compromised kidney function who should use it with caution. Patients with kidney impairment should adjust the dosing intervals and frequently monitor their kidney condition. Special caution is necessary when taking this medication with other drugs that may affect kidney function. Given that this drug may affect bone health, patients with bone pain or a risk of fractures should regularly check their bone condition. Because it contains sodium bisulfite, some patients may experience allergic reactions or asthma symptoms, so those with hypersensitivity should exercise caution. It can be relatively safely used during pregnancy, but it should be used only when necessary, and breastfeeding should be avoided. The safety and efficacy in children under 12 years old or weighing less than 35 kg have not been established. Elderly patients should take care when using this medication, considering the possibility of liver and kidney function decline. In case of overdose, immediately inform a healthcare professional, and if necessary, the drug can be removed through hemodialysis. This medication should be stored at room temperature and kept in a secure place out of reach of children. During treatment, regularly check weight, blood sugar, and lipid levels, and if any unusual symptoms appear, consult a doctor immediately. There may be drug interactions with this medication, so if other medications are being taken, please inform a healthcare professional.

• Worsening of hepatitis
• hypersensitivity
• acute renal failure
• Fanconi syndrome
• hypophosphatemia
• tubular injury
• bone pain
• limb pain
• fractures
• muscle pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 degree and 30 degrees Celsius. This helps to keep the drug’s efficacy and safety intact for a long time.

Appearance

Light blue almond-shaped film-coated tablet

Package unit

30 tablets/bottle