Prired Tablet (Tenofovir Disoproxil)

Adult dose

Adults: For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet once daily (equivalent to 245mg of tenofovir disoproxil). It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. In patients with mild renal impairment, no dose interval adjustment is necessary (creatinine clearance 50-80mL/min). Creatinine clearance (mL/min)a ≥50: Recommended interval for taking 300mg: every 24 hours Creatinine clearance (mL/min)a 30-49: Recommended interval for taking 300mg: every 48 hours Creatinine clearance (mL/min)a 10-29: Recommended interval for taking 300mg: every 72-96 hours Patients on hemodialysis: Recommended interval for taking 300mg: every 7 days or approximately 12 hours after completion of hemodialysisb a. Calculated using ideal (lean) body weight. b. Assuming 3 hemodialysis sessions per week, each lasting approximately 4 hours, administer once weekly. This medicine should be administered after hemodialysis is completed. The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance <10mL/min who are not receiving hemodialysis; therefore, no dosage recommendations are available for these patients.

Child dose

Pediatric patients aged 12 years and older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet once daily (equivalent to 245mg of tenofovir disoproxil). It may be taken with or without food. Pediatric patients with chronic hepatitis B who weigh less than 35kg: Safety and efficacy have not been established. Pediatric patients with renal impairment: There are no data to provide dosage recommendations.

Stopping this medication can lead to a rapid worsening of hepatitis, so patients who discontinue treatment should be monitored regularly for liver status over a long period. People who are allergic to this medication or its components should not take it, and it should not be used in cases of certain genetic disorders, such as lactose intolerance. Co-administration with certain specific medications is prohibited, so it's essential to discuss the combination therapy with a physician. This medication contains pigments that may cause allergies, and sensitive patients should exercise caution. Since this medication is predominantly excreted through the kidneys, patients with poor kidney function should undergo kidney function tests before taking it and should also be monitored regularly for kidney status during treatment. Patients with decreased kidney function should adjust the dosing intervals and should not take it with other drugs that may burden the kidneys. Due to potential effects on bone health, patients at risk of bone pain or fractures should consider bone density testing and may be advised to supplement calcium and vitamin D if necessary. Common side effects during treatment may include diarrhea, headache, nausea, rash, etc. If adverse symptoms persist or worsen, a doctor's consultation is required. It can be used relatively safely during pregnancy, but medication should only be taken under a doctor's guidance, and nursing mothers are recommended to avoid breastfeeding. Children and the elderly should carefully consider the dosage and the decision to take it based on kidney function and overall health status. In case of overdose, patients should visit a hospital immediately for proper treatment, and the components of this medication can be partially removed through dialysis. This medication should be stored away from direct sunlight and at room temperature, in a secure place out of reach of children.

• Worsening of hepatitis
• hypersensitivity
• acute renal failure
• Fanconi syndrome
• kidney impairment
• bone pain
• limb pain
• fractures
• muscle pain
• proximal tubular dysfunction

This medication may be sensitive to air and moisture, so it must be stored in a sealed container. The recommended storage temperature is between 1 degree and 30 degrees Celsius at room temperature to maintain its efficacy over time.

Appearance

Light blue almond-shaped film-coated tablet

Package unit

30 tablets per bottle