Febuxostat 40mg (Febuxostat)

Adult dosage

1. Adults Administer this medicine at a dose of 40mg or 80mg once daily, with or without food. This medicine acts very rapidly; recheck serum uric acid levels after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dosage adjustment is required in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). 3. Patients with hepatic impairment No special dosage adjustment is required in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child-Pugh Class C).

This medication may increase the risk of cardiovascular death in patients with cardiovascular diseases, so it should be used with caution in those with a history of cardiovascular disease. It should not be administered to patients with hypersensitivity to the active ingredient or excipients, and to those currently taking certain medications such as mercaptopurine or azathioprine. Since it contains lactose, patients with lactose intolerance or related genetic issues should not take this medication. Patients with liver disease or thyroid dysfunction are recommended to have regular liver function and thyroid function tests while taking this medication. Patients with heart disease or heart failure, and those taking the medication theophylline need to exercise caution due to potential drug interactions. This medication may temporarily increase gout attacks during the initial period of administration, so it should be started only after gout attacks have completely subsided, and if attacks occur during treatment, they should be managed properly without stopping the medication. Liver function abnormalities may occur, so if symptoms such as malaise, loss of appetite, or jaundice appear, consult a doctor immediately and undergo liver function tests. This medication can cause drowsiness, dizziness, or numbness, so caution is needed when driving or operating machinery. Severe allergic reactions or hypersensitivity may rarely occur, so if symptoms such as skin rashes, difficulty breathing, or swelling appear, stop the medication immediately and consult a healthcare professional. This medication can interact with certain drugs, so inform your doctor or pharmacist about any other medications you are taking. It is safest not to take this medication while pregnant or breastfeeding. It is advisable not to use it in children or adolescents under 18 years of age as there is no experience of administration in this group. In case of overdose, there are no specific antidotes available, and treatment and supportive care according to symptoms is required. This medication should be kept out of reach of children, and specific storage conditions are not required.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, dyspnea, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal ECG, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, melena, oral ulcers, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, mood disturbances, gait disturbances, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes insipidus, fatty liver disease, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle single contraction, muscle constriction, muscle weakness, musculoskeletal pain, muscle rigidity, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, hyposmia, heat stroke, drowsiness, mental disorders, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, neurosis, panic attack, personality changes, hematuria, nephrolithiasis, increased urinary frequency, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, dyspnea, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, vascular edema, dermatitis, skin urticaria, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechiae, photosensitivity, pruritus, purpura, skin discoloration, pigment deposition changes, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolonged activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocytes, decreased neutrophils, increased leukocytes, decreased leukocytes, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, urine leukocyte positive, urine protein positive, bruise, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reaction, hypersensitivity reaction, eosinophilia, systemic symptoms associated with drug reactions, fever, hematological disorders, renal disorders, liver disorders, liver failure, jaundice, hepatic dysfunction, agranulocytosis, rhabdomyolysis

This medication may be sensitive to air or moisture, so it must be stored in a tightly sealed container. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature. By storing it this way, the efficacy of the medication can be maintained for a longer period.

Appearance

White to light yellow round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle