Nepocure Injection (Nepofam Hydrochloride)

Adult administration

Administer 20 mg of nefopam hydrochloride per dose by intramuscular or intravenous injection. If necessary, repeat every 6 hours, not exceeding 120 mg per day. Administer the intravenous injection slowly over at least 15 minutes. After administration, it is preferable to have the patient remain lying down and rest for 15-20 minutes. If added to an infusion solution such as electrolytes or glucose, administer 30 mg over 4 hours or 40 mg over 6-8 hours, according to the infusion time. Mixing this medication with other drugs for injection is not recommended. Adjust the dose as appropriate according to age and symptoms.

This medication may contain glass fragments when using a glass ampule; therefore, one must exercise extreme caution when cutting the injection container. This medication should not be used in patients with epilepsy, myocardial infarction, those taking certain antidepressants, individuals with drug allergies, children under 15 years old, individuals with a history of seizures, those with urethra or prostate problems, and patients with glaucoma associated with increased intraocular pressure. Caution should be exercised when administering this medication to the elderly, pregnant or breastfeeding women, and patients on anticholinergic medications. Side effects may include decreased appetite, nausea, drowsiness, vomiting, excessive sweating, dizziness, rapid heartbeat, thirst, urinary retention, injection site pain, headaches, blurred vision, fatigue, irritability, sleep disturbances, hallucinations, drug dependence, seizures, and allergic reactions. The incidence of side effects may vary with the dosage of the drug, and generally, they tend to decrease with repeated administration. This medication should be used considering the severity of symptoms such as inflammation, pain, and fever; long-term use is not recommended. When treating inflammation caused by infection, it should be used cautiously with appropriate antibiotics or antifungals, and the patient's condition should be closely monitored. In the elderly, administer the minimum effective dose and pay particular attention to the occurrence of side effects, as individuals with reduced liver or kidney function may be affected by the drug's metabolism and excretion. This medication may cause drowsiness or decreased concentration; therefore, it is advisable to avoid use when driving or operating machinery. Caution is advised when using this medication in conjunction with other analgesics or anticholinergic drugs as side effects may increase. Use of this medication is not recommended during pregnancy or breastfeeding. Safety and efficacy have not been established for children under 15 years old; hence, it should not be used in this age group. Elderly patients are not recommended to use this medication due to anticholinergic side effects. In the event of an overdose, seek medical advice immediately, as close observation of cardiac and respiratory status may be required. This medication should be avoided from being mixed with other medications for injection and should be stored in a sealed container to prevent access from children, in a cool and dry place. Additionally, avoid direct sunlight and do not transfer to another container for safety.

• Loss of appetite
• gastrointestinal disorders
• nausea
• drowsiness
• vomiting
• excessive sweating
• dizziness
• tachycardia
• palpitations
• thirst

This medication should be stored in a sealed container to prevent air or moisture from entering, ideally at a temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the drug's efficacy and prevent deterioration.

Appearance

Transparent glass ampule containing a colorless transparent liquid

Package unit

2mL/ampule X 50