Vesibojung (Becipvovir Diphosphate Malate)

Adult dose

In adults, administer 1 tablet (equivalent to 150mg of besifovir dipivoxil) orally once daily. To prevent a decrease in serum L-carnitine levels while taking this medicine, administer L-carnitine 660mg concomitantly. This medicine may be taken with or without food. Patients with mild renal impairment: No dosage adjustment is required. Patients with moderate or severe renal impairment: The recommended dosage is 1 tablet every 2 days for moderate impairment and 1 tablet every 4 days for severe impairment. Patients with end-stage renal disease: Use of this medicine is not recommended because there is no treatment experience.

This drug is a nucleoside analogue that may affect the liver; therefore, caution is required, particularly in women, obese patients, and patients with risk factors for liver disease. If there are suspicions of liver dysfunction or lactic acidosis, stop taking the medication immediately. Irrespective of discontinuation, there may be a rapid deterioration of hepatitis B, hence regular liver function tests should be carried out as per doctor's instructions. HIV infection status must be confirmed before treatment initiation, and this drug should not be used in patients with HIV infection. Individuals with allergies to this drug or its components should not take it, and patients with lactose intolerance or specific genetic metabolic disorders should also avoid it. Patients with compromised kidney function or those taking other drugs that affect renal excretion may experience increased serum drug concentrations when using this medication; hence, careful monitoring is necessary. This drug may cause a variety of side effects including infections, dyspepsia, fatigue, headaches, muscle pain, skin rashes, and especially increases in liver enzyme levels, so regular blood tests are required. Pregnant women should use this medication cautiously considering potential risks to the fetus, and nursing mothers should avoid breastfeeding while taking this drug. Safety in children and adolescents has not been established, and elderly individuals should be particularly cautious due to the likelihood of reduced kidney and liver function. In case of overdose, contact a medical institution immediately for appropriate treatment, and the effect of this medication on driving or machine operation remains unclear, so caution is advised. Lastly, this medication should be stored out of reach of children, and should not be transferred to other containers.

• Lactic acidosis
• severe hepatomegaly
• moderate muscle cramps
• nasopharyngitis
• dyspepsia
• fatigue
• headache
• increased alanine aminotransferase (ALT)
• lumbar pain
• itching

Store this medication in a tightly closed container to prevent air or moisture ingress. It is advisable to maintain storage temperatures between 1 to 30 degrees Celsius.

Appearance

White, round tablet

Package unit

30 tablets/bottle