Arizen 5 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Donepezil hydrochloride: Administer 5 mg once daily before bedtime. After 15 days, a stable condition is reached, hence maintain the 5 mg dose for 4-6 weeks. After evaluating clinical response, it may be increased to 10 mg. Care should be taken for gastrointestinal adverse reactions when increasing to 10 mg daily. Underweight women aged 85 years and older should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience of use in pediatric patients, so administration is not recommended.

This medication contains Donepezil Hydrochloride Monohydrate as the main ingredient for the treatment of symptoms of Alzheimer's type dementia. This medication should not be administered to certain patients, including those who are allergic to Donepezil or any of its components, pregnant women, or breastfeeding mothers. Additionally, patients with lactose intolerance or genetic lactose metabolism disorders should not take this medication. Patients with heart disease or conduction disturbances should use this medication cautiously, as it may slow heart rate or cause arrhythmia. Caution is also needed for patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcers, as it may increase the risk of gastrointestinal bleeding or worsening of ulcers. Patients with asthma or obstructive pulmonary disease should be careful, as this medication may worsen symptoms due to bronchoconstriction and increased mucus secretion. Patients with extrapyramidal disorders like Parkinson's disease should use this medication cautiously as it may worsen their symptoms. Severe side effects such as fainting, heart issues, gastrointestinal bleeding, liver dysfunction, seizures, and movement disorders may occur while taking this medication; if any abnormal symptoms arise, consult a physician immediately. Additionally, common side effects like nausea, vomiting, diarrhea, insomnia, dizziness, headache, and fatigue may occur, so caution is necessary. This medication is not approved for other forms of memory impairment besides Alzheimer's type dementia, and treatment effects should be regularly evaluated. Patients with heart disease or electrolyte imbalances may be at risk for cardiac side effects and may require electrocardiogram testing. As this medication may affect driving or machinery operation, caution is required in the early stages of treatment or following dose adjustments. Pregnant or breastfeeding women should avoid using this medication unless absolutely necessary and should consult with a healthcare professional first. This medication may interact with other drugs, particularly heart medications, antidepressants, antibiotics, and anticonvulsants, hence caution is required when used in combination. In case of overdose, severe symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate medical treatment, and antidotes like atropine may be used. This medication should be kept out of reach of children, and transferring it to other containers should be avoided to prevent quality degradation or accidents.

Serious side effects

• Hives, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, pallor (severe allergic reaction)
• Severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa (severe skin adverse reactions)
• Shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever (respiratory issues)
• Jaundice (yellowing of skin or eyes), extreme lethargy (liver dysfunction)
• Sudden and very severe

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• drowsiness
• muscle pain

This medication should be stored in a tightly closed container to prevent air and moisture from entering. It is recommended to keep the storage temperature between 1 to 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle