Inazole 100 mg (Itraconazole Solid Dispersion)

Adult dosage

Administration immediately after meals is preferable. 1. Short-term treatment The final clinical and mycological response should preferably be assessed 2～4 weeks after completion of the prescribed treatment. Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. Pityriasis versicolor: Administer 200 mg once daily for 7 days. Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. Tinea manuum (palm), tinea pedis (sole): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. Oropharyngeal candidiasis: Administer 100 mg once daily for 15 days. Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis Pulse therapy: Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period; this constitutes 1 cycle. Administer up to 2 cycles for infection limited to the fingernails and up to 3 cycles for toenail infection. Continuous therapy: Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after treatment ends. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this drug may be reduced; therefore, if necessary, double the dose. Aspergillosis: 200mg once daily; average treatment duration 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily; average treatment duration 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily; average treatment duration 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily; average treatment duration 6 months.

This medication can be life-threatening in patients with decreased cardiac function, especially those with congestive heart failure, so it should not be used unless for treatment of serious infections. If heart failure symptoms develop during treatment, use should be discontinued immediately. Patients with a history of hypersensitivity to this drug or specific heart diseases should avoid taking it. Additionally, this medication interacts severely with many drugs, so it should not be taken with contraindicated medications. Pregnant or potentially pregnant women, as well as nursing mothers, should not use this medication, and especially women who may become pregnant should use effective contraception until the next menstrual period after taking this drug. Patients with impaired liver function or those with a history of hepatotoxicity should regularly undergo liver function tests while taking this medication, and patients with impaired kidney function may also require dosage adjustments. Immunocompromised patients or those with specific neuropathy symptoms should be monitored closely during use. Rarely, serious adverse effects such as hepatotoxicity, cardiac issues, allergic reactions, neurological disturbances, and hearing loss may occur, so healthcare professionals should be consulted immediately if any abnormal symptoms appear. Dizziness, visual disturbances, and hearing loss may occur during use, so caution is needed when driving vehicles or operating machinery. This medication may have reduced absorption in low gastric acidity, so it is recommended to take it with acidic drinks if taking medications that reduce gastric acidity. In the case of overdose, there is no specific antidote, so treatment should be symptomatic, and it should be kept out of reach of children. Lastly, due to its potential for numerous drug interactions, it is essential to inform healthcare professionals about any currently taken medications and to avoid concurrent use with contraindicated drugs.

• Headache
• nausea
• abdominal pain
• rhinitis
• sinusitis
• upper respiratory tract infection
• leukopenia
• hypersensitivity
• taste disorder
• sensory impairment

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, at a temperature between 1°C and 30°C (room temperature). Storing it this way helps maintain the drug's effectiveness and prevents degradation.

Appearance

Round film-coated tablets that are white or light yellow

Package unit

28 tablets/bottle, 100 tablets/bottle