Prismasol 2 Potassium Solution

Adult dosage

The fluid substitution rate for blood filtration and hemodialysis is 500 - 3000 ml/h. For continuous hemodialysis and continuous venovenous hemofiltration, the dialysis fluid rate is 500 - 2500 ml/h. Generally used rates are about 2000 - 2500 mL/h, and the daily fluid volume is approximately 48 - 60 L. In cases where it is used for intravenous application and as fluid substitutes for hemodialysis, blood filter.

Children's dosage

The fluid substitution rate for blood filtration and hemodialysis is 1000 - 2000 mL/h/1.73 m2. Especially for younger children (≤10 kg), a maximum of 4000 mL/h/1.73 m2 or less is required.

This product should not be used in certain patients. For example, it is contraindicated in patients with known allergies to this product, those with low serum potassium levels, patients with metabolic alkalosis, individuals with severe renal failure who do not improve with blood filtration in uremia, patients with insufficient arterial pressure during vascular access, and patients who are at high risk for bleeding while receiving systemic anticoagulation therapy. Caution is needed as adverse reactions may occur while using this product. Fluid imbalance, electrolyte disturbances, hyperglycemia, metabolic alkalosis or acidosis, hypotension, nausea and vomiting, and muscle cramps may occur. Adverse reactions related to hemodialysis have been reported. This product should be used under the supervision of an experienced physician in blood filtration or hemodialysis, and during treatment, serum potassium levels, hemodynamic status, fluid balance, electrolytes, and acid-base balance should be closely monitored. Phosphate levels should also be checked periodically, and inorganic phosphate supplementation should be provided in cases of hypophosphatemia. Diabetic patients should regularly check their blood sugar levels, and if hyperglycemia occurs, switching to a dextrose-free solution or additional measures may be necessary. Patients with fluid imbalance should be carefully monitored regarding their clinical status, and measures should be taken to restore normal fluid balance. Since this product contains potassium, there is a risk of hyperkalemia. If hyperkalemia occurs after treatment initiation, potassium sources should be checked, and the infusion rate should be reduced or discontinued if necessary. If hyperkalemia persists, potassium-free dialysis solutions can be used to promote potassium removal. Patients with corn allergies should not use this product, and if an allergic reaction is suspected, administration should be immediately stopped and appropriate treatment should be received. This product may interact with other medications during blood filtration or hemodialysis, so adjustments should be made considering changes in the concentration of the medications being treated. Caution should particularly be exercised when used in conjunction with sodium bicarbonate or citrates, as there is a risk of metabolic alkalosis or changes in calcium levels. Safety during pregnancy or lactation has not been established, so the benefits and risks should be carefully evaluated before use. In case of an overdose, fluid overload, electrolyte, and acid-base imbalances may occur, and in such cases, administration should be discontinued and appropriate interventions taken. No specific antidotes for overdose are available, so careful monitoring during treatment is essential. This product should only be used in an environment equipped with appropriate renal replacement therapy devices, and prior to use, the solution should be verified to be clear and free from discoloration or precipitate. The mixed solution should be prepared in a sterile manner and should be used immediately; any unused solution should be discarded. The solution may be warmed to 37 degrees Celsius, but it should not be heated in a microwave or with water; only dry heat methods should be used. Furthermore, this product should not be mixed with other medications, and compatibility should always be confirmed. When storing, it should be kept in a sealed container to prevent air or moisture from entering, and it is recommended to store in a cool place between 4 and 30 degrees Celsius. By storing in this manner, the effectiveness of the medication can be maintained, and degradation can be prevented.

Mild side effects

• Fluid imbalance
• hypotension
• nausea
• vomiting
• muscle cramps
• hyperglycemia
• hypophosphatemia
• hypokalemia
• metabolic alkalosis
• metabolic acidosis

This product should be stored in a sealed container to prevent air or moisture infiltration, ideally in a cool place between 4 and 30 degrees Celsius. Storing in this way will help preserve the drug's efficacy and prevent degradation.

Appearance

A slightly transparent yellow blood dialysis filtrate after mixing

Package unit

5000 ml / pack