Neopat 150 mg (Lacosamide)

Adult dose

This drug should be taken twice daily. The recommended initial dose is 50mg twice daily; after 1 week, increase to 100mg twice daily. Depending on clinical response and tolerability, the maintenance dose may be increased by 50mg per dose twice daily each week. The maximum recommended dose is 400mg per day (200mg twice daily). If treatment with this drug is to be discontinued, gradual dose reduction is recommended. (e.g., gradually reduce the daily dose by 200mg each week) This drug may be taken with or without food. 1. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment (CLCR>30mL/min). A maximum dose of 300mg per day is recommended for patients with severe renal impairment (CLCR≤30mL/min) and patients with end-stage renal disease. Since this drug is removed from plasma by hemodialysis, an additional dose of up to 50% of the single dose is recommended immediately after hemodialysis in patients receiving hemodialysis. Treatment of patients with end-stage renal disease should be undertaken with caution because clinical experience is limited and accumulation of a metabolite (with unknown pharmacological activity) may occur. Dosage adjustment should be performed carefully in all patients with renal impairment. 2. Patients with hepatic impairment The dose should be selected with caution in patients with hepatic impairment. A maximum dose of 300mg per day is recommended in patients with mild or moderate hepatic impairment. Use is not recommended in patients with severe hepatic impairment. 3. Elderly patients Dose reduction is not necessary in elderly patients. Experience with lacosamide in elderly patients with epilepsy is limited; however, the decrease in renal clearance and increase in AUC associated with age should be taken into consideration in elderly patients. (See section on patients with renal impairment.)

Child dose

Use of this drug is not recommended in children and adolescents under 16 years of age because data on safety and efficacy in these age groups are not available.

This medication may increase the risk of suicidal thoughts or behavior, so if mood changes or depression symptoms appear during treatment, it is essential to inform healthcare professionals immediately. Individuals with allergies to the active ingredient or any component of this medication should not take it. Dizziness or motor control issues may occur, so caution should be exercised when starting this medication to prevent falls or accidents. Patients with heart disease or conduction abnormalities must have an ECG before taking this drug and should be monitored by healthcare professionals. This medication can cause psychiatric side effects such as depression, suicidal thoughts, or mood changes, so both patients and caregivers should notify healthcare professionals immediately if these symptoms arise. Serious allergic reactions such as multiorgan hypersensitivity can occur; hence, if symptoms like fever, rash, or liver or kidney issues appear, the patient should stop taking the medication and see a doctor immediately. Common side effects during treatment may include dizziness, headache, nausea, and diplopia; these symptoms tend to decrease over time. Avoid driving or operating hazardous machinery until dizziness and visual disturbances have fully resolved. Interactions with other medications may occur, so if the patient is taking any other drugs, they must inform their healthcare providers, particularly with medications affecting the heart. Elderly patients can take the medication without specific dosage adjustment, but caution is advised based on individual health status. This drug is not recommended for children under 16 years, as safety and efficacy data are not confirmed in this age group. During pregnancy, this medication may affect the fetus, so it should only be taken if necessary and with consultation from healthcare professionals if pregnancy is planned. For breastfeeding mothers, the drug may be excreted in breast milk and affect the baby; therefore, it is advised to discontinue breastfeeding during treatment. In the case of overdose, symptoms such as dizziness, nausea, and vomiting may appear, and as there is no specific antidote, immediate medical treatment should be sought. This medication may cause a psychological dependence similar to that of a euphoric state, so it must be taken precisely as directed by a healthcare professional. When storing, keep it out of reach of children and do not transfer it to another container.

suicidal thoughts, suicidal behavior, depression, dizziness, ataxia, prolonged PR interval, second-degree or higher atrioventricular block, slow or irregular pulse, fainting, palpitations, fast or irregular pulse, shortness of breath, multiorgan hypersensitivity reaction, headache, nausea, double vision, confusion, insomnia, mood changes, depressed mood, cognitive impairment, eye twitching, balance disorder, coordination disorder, memory impairment, tremors, drowsiness, speech disorder, attention deficit, sensory loss, paresthesia, cerebellar syndrome, blurred vision, vertigo, tinnitus, vomiting, constipation, abdominal distension, dyspepsia, dry mouth, diarrhea, oral hypoaesthesia, muscle cramps, itching, walking difficulties, asthenia, fatigue, hypersensitivity, feeling intoxicated, fever, falls, skin laceration, contusion, neutropenia, anemia, palpitations, AV block, syncope, bradycardia, atrial fibrillation, atrial flutter, abnormal liver function tests, agranulocytosis, drug hypersensitivity, euphoria, suicide attempt, aggressiveness, anxiety, psychotic disorder, hallucinations, bradycardia, cardiac asystole, cardiac arrest, death, toxic epidermal necrolysis, Stevens-Johnson syndrome, rash, angioedema, urticaria, convulsions, psychogenic seizures, ataxia, sedation, alopecia, blistering, early satiety, weight gain, decreased appetite, urinary incontinence, hiccups

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain storage at room temperature between 1 to 30 degrees Celsius.

Appearance

Peach-colored oval film-coated tablet

Package unit

100 tablets (10 tablets/PTP x 10), 30 tablets/bottle, 100 tablets/bottle