Keppra XR Extended-Release Tablet 500 Milligrams (Levetiracetam)

Adult dose

As this medicine is an extended-release tablet, swallow it whole without crushing, splitting, or chewing. This medicine may be taken regardless of meals and should be taken with plenty of water. The daily dose is taken once daily. Monotherapy and adjunctive therapy for partial-onset seizures (12 years and older) Adults (18 years and older) Initiate treatment with this medicine at 1,000 mg once daily. Depending on clinical response and tolerability, the dose may be increased or decreased by 1,000 mg once daily every 2 weeks; the maximum recommended dose is 3,000 mg daily. Patients with renal impairment: Because levetiracetam clearance is related to renal function, administer individually according to the patient's renal function. Adult patients with renal impairment Normal, creatinine clearance ≧ 80 (mL/min/1.73m2): dose per administration 1,000-3,000 mg, once daily (24-hour interval) Mild, creatinine clearance 50-79 (mL/min/1.73m2): dose per administration 1,000-2,000 mg, once daily (24-hour interval) Moderate, creatinine clearance 30-49 (mL/min/1.73m2): dose per administration 500-1,500 mg, once daily (24-hour interval) Severe, creatinine clearance < 30 (mL/min/1.73m2): dose per administration 500-1,000 mg, once daily (24-hour interval) Patients with hepatic impairment: No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, creatinine clearance may underestimate renal failure. Therefore, if creatinine clearance is less than 60mL/min/1.73m2, it is recommended to reduce the daily maintenance dose by 50%. Older adults (65 years and older): Dose adjustment is recommended in older patients with reduced renal function.

Child dose

Monotherapy and adjunctive therapy for partial-onset seizures (12 years and older) Adolescents (12~17 years) weighing 50 kg or more: Initiate treatment with this medicine at 1,000 mg once daily. Depending on clinical response and tolerability, the dose may be increased or decreased by 1,000 mg once daily every 2 weeks; the maximum recommended dose is 3,000 mg daily.

This medication is used for the treatment of epilepsy and may increase the risk of suicidal thoughts or behaviors, as well as mental health issues such as depression during treatment. Therefore, patients and caregivers should immediately inform healthcare professionals if these symptoms appear. Additionally, this medication can cause central nervous system side effects such as drowsiness, fatigue, coordination disorders, and behavioral abnormalities; caution is advised. These symptoms may frequently occur especially within the first 4 weeks of treatment. Discontinuing this medication abruptly may worsen seizures, so the dosage should be reduced gradually according to a doctor's instructions. Patients who are allergic to any of the ingredients in this medication or similar drugs should not be administered this medication. Patients with impaired renal function may require dosage adjustments, and those with severe liver function impairment should first undergo renal function tests. There may be side effects related to a decrease in blood cell counts, so blood tests are recommended if symptoms such as fever, weakness, or signs of infection occur. This medication may cause changes in behavior such as irritability and aggression and psychiatric symptoms, so consultation with a physician is necessary if these symptoms occur. Furthermore, if seizure symptoms worsen, immediate consultation with healthcare professionals is advised. Caution is needed for patients with heart conditions or abnormalities on electrocardiograms. This medication may affect the fetus during pregnancy, so women who are pregnant or planning to become pregnant should definitely consult a healthcare professional. Nursing mothers should consider stopping breastfeeding or the medication, as this drug may be excreted in breast milk and affect the infant. Safety for children and the elderly has not been sufficiently established, and older adults may require dosage adjustments due to impaired renal function. Drowsiness or decreased concentration may occur due to this medication when driving or operating machinery, so caution is advised, and it is recommended to avoid hazardous tasks if possible. In case of overdose, symptoms like drowsiness, aggression, or reduced consciousness may appear, and immediate emergency treatment is required. This medication has relatively low interaction with other drugs, but caution is necessary when used in combination with certain medications, so patients must inform healthcare professionals of all medications they are taking. Finally, this medication should be stored out of reach of children, and it is safest not to transfer it to another container.

• Suicidal thoughts
• suicidal behavior
• depression
• abnormal changes in mood and behavior
• drowsiness
• fatigue
• coordination disturbances
• abnormal behavior
• weakness
• irritability

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is recommended to maintain storage temperatures between 1°C and 30°C.

Appearance

White oblong extended-release film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP×3]