Vimscape Tablets 100 mg (Lacosamide)

Adult dose

This medicine should be taken twice daily. The recommended initial dose is 50mg twice daily, and after 1 week it should be increased to 100mg twice daily. Depending on clinical response and tolerability, the maintenance dose may be increased by 50mg per dose twice daily each week. The maximum recommended dose is 400mg/day (200mg per dose, twice daily). If treatment with this medicine is to be discontinued, gradual dose reduction is recommended. (e.g., gradually reduce the daily dose by 200mg each week) This medicine may be taken with or without food. 1. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment (CLCR>30mL/min). A maximum dose of 300mg/day is recommended for patients with severe renal impairment (CLCR≤30mL/min) and patients with end-stage renal disease. Since this medicine is removed from plasma by hemodialysis, an additional dose of up to 50% of the single dose is recommended immediately after hemodialysis for patients receiving hemodialysis. Use caution when treating patients with end-stage renal disease because clinical experience is limited and metabolites (whose pharmacological activity is unknown) may accumulate. Dose adjustment should be performed carefully in all patients with renal impairment. 2. Patients with hepatic impairment Use caution with dosing in patients with hepatic impairment. A maximum dose of 300mg/day is recommended in patients with mild or moderate hepatic impairment. Use is not recommended in patients with severe hepatic impairment. 3. Older adults No dose reduction is necessary in older adults. Although experience with lacosamide in older adults with epilepsy is limited, the age-related decrease in renal clearance and increase in AUC should be taken into consideration in older adults. (See the section on Patients with Renal Impairment.)

Child dose

Use in these age groups is not recommended because data on safety and efficacy in children and adolescents under 16 years of age are unavailable.

This medication may increase the risk of suicidal thoughts or behaviors, so mood changes or depressive symptoms should be carefully monitored during treatment. Do not take this medication if you have an allergy to any of its components. Dizziness may occur, increasing the risk of falling or injury, so caution is especially necessary during the initial stages of use. Patients with heart disease or cardiac conduction abnormalities should have an ECG test before taking this medication and follow the doctor's instructions. This medication may worsen mental health issues such as depression, mood changes, and suicidal thoughts, so any symptoms should be reported to medical personnel immediately. During treatment with this medication, multi-organ hypersensitivity reactions such as rash, fever, and eosinophilia may occur; if these symptoms appear, discontinue use immediately and seek medical attention. Common side effects include dizziness, headache, nausea, visual disturbances, but these symptoms often subside over time. Avoid dangerous activities such as driving or operating machinery until fully aware of the medication's effects. Interactions may occur when taken with other medications, so be sure to inform medical personnel of any medications currently being taken. No special dosage adjustment is needed for the elderly, but caution may be necessary based on physical condition. Safety and efficacy for children and adolescents under 16 years of age have not been established, so use is not recommended. Women who are pregnant or planning to become pregnant should consult carefully regarding the use of this medication, and nursing mothers should discontinue breastfeeding while taking it. Overdose may lead to symptoms such as dizziness, nausea, and vomiting, and since there are no specific antidotes, seek appropriate medical treatment immediately. This medication may cause the potential for psychological dependence, so sudden discontinuation during treatment should be avoided and discussed with medical personnel. Store in a safe place away from children's reach, and do not transfer to another container.

Suicidal thoughts, suicidal behavior, depression, abnormal changes in mood and behavior, dizziness, ataxia, prolonged PR interval, second-degree or higher atrioventricular block, atrial fibrillation, atrial flutter, palpitations, slow or irregular pulse, fainting, dizziness, headache, nausea, diplopia, cognitive impairment, eye twitching, balance disorder, coordination disorder, memory impairment, tremors, drowsiness, speech disturbance, attention deficit, sensory loss, paresthesia, cerebellar syndrome, blurred vision, vertigo, tinnitus, vomiting, constipation, abdominal distension, dyspepsia, dry mouth, diarrhea, diminished tactile sensation in the mouth, muscle cramps, itching, gait disturbance, asthenia, fatigue, hypersensitivity, feeling intoxicated, fever, falls, skin lacerations, contusions, neutropenia, anemia, atrioventricular block, syncope, bradycardia, abnormal liver function tests, agranulocytosis, drug hypersensitivity reaction, euphoria, suicide attempt, aggression, anxiety, psychotic disorder, insomnia, hallucinations, bradycardia, deep vein thrombosis, cardiac asystole, cardiac arrest, death, toxic epidermal necrolysis, Stevens-Johnson syndrome, rash, angioedema, urticaria, convulsions, psychogenic seizures, ataxia, sedation, hair loss, blisters, early satiety, weight gain, loss of appetite, urinary incontinence, hiccups, stiffening-tonic seizures, status epilepticus, electrocardiogram abnormalities, cardiac arrest

This medication should be stored in a tightly sealed container to protect it from air and moisture. The recommended storage temperature is between 1 degree and 30 degrees Celsius at room temperature. Storing it this way ensures the safe retention of the medication's effectiveness.

Appearance

Pale yellow oval film-coated tablet

Package unit

Bottle packaging - 30 tablets/bottle, Bottle packaging - 200 tablets/bottle