Zeropion Extended-Release Tablet 150mg (Bupropion Hydrochloride)

Adult dose

This medicine should be swallowed whole; do not crush, divide, or chew it. Doing so may increase the risk of adverse reactions, including seizures. Short-term adjunctive treatment of nicotine dependence when stopping smoking As an initial dose, administer 150mg once daily for 6 days, then increase to 150mg twice daily. The interval between doses should be at least 8 hours. The maximum dose per administration should not exceed 150mg, and the total daily dose should not exceed 300mg. This medicine should be administered to the patient for at least 7 weeks. If the patient's condition has not progressed significantly toward smoking cessation by week 7 of treatment, consider discontinuing this medicine, as the patient is unlikely to stop smoking during that quit attempt. Combination therapy with this medicine and a nicotine patch: When this medicine is administered in combination with a nicotine patch to treat nicotine dependence, no change in the dosage regimen is necessary. Start combination treatment with the nicotine patch on the target quit date. Before combination treatment, the physician should be thoroughly familiar with the prescribing information for both this medicine and the nicotine patch. Depression It is also important to increase the dose gradually to minimize agitation, extremely restless behavior, and insomnia, which are frequently observed at the beginning of treatment. If necessary, these effects may be managed by temporarily reducing the dose or administering a sedative-hypnotic with an intermediate or long duration of action for a short period; however, a sedative-hypnotic is usually not needed after the first week of treatment. Dosing at times other than bedtime may minimize insomnia, and dose increases should be stopped if the patient complains of distress due to persistent adverse reactions. Initial dose: The usual target dose of this medicine in adults is 150mg twice daily (300mg/day). Administer 1 tablet once in the morning (150mg/day, 150mg once daily) for at least 4 days. If the patient tolerates it adequately, increase the dose to 1 tablet twice daily (300mg/day, 150mg twice daily), allowing an interval of at least 8 hours between doses. Dose increase above 300mg/day: In patients whose symptoms have not improved after treatment with a dose of 300mg/day for several weeks, an increase to a maximum of 400mg/day (200mg twice daily) may be considered. Maintenance dose: Long-term efficacy was demonstrated when patients with recurrent major depressive disorder who had responded to 8 weeks of acute treatment with this medicine were randomized to receive placebo or the same dose of this medicine (150mg twice daily) as maintenance therapy for 44 weeks. Patients with hepatic impairment: Extreme caution should be exercised when administering this medicine to patients with severe cirrhosis, and the dose in these patients should not exceed 100mg daily or 150mg every 2 days. This medicine should be administered with caution to patients with hepatic impairment (including mild to moderate cirrhosis); in patients with mild to moderate cirrhosis, reducing the frequency of administration and/or the dose should be considered. Patients with renal impairment: This medicine should be administered with caution to patients with renal impairment; reducing the frequency of administration and/or the dose should be considered.

Child dose

The safety and efficacy of this medicine in patients under 18 years of age have not yet been established.

This medication is used for the treatment of depression and smoking cessation. There may be an increased risk of suicidal thoughts or behavior while taking this medication, especially in young patients aged 18 to 24 years. Therefore, physicians should carefully assess the necessity and risks of this medication. This medication is not approved for use in children and adolescents, and it is advisable not to use it in patients under 18 years of age. It should also be avoided or used with extreme caution in patients with a history of seizures or those at high risk of seizures, patients with impaired liver or kidney function, and patients with certain psychiatric disorders. The risk of seizures may increase with dosage, so it is essential to adhere to the recommended dosage and interval, avoiding sudden dosage increases. Additionally, this medication should not be taken concurrently with other bupropion-containing products. During treatment, neuropsychiatric symptoms such as agitation, insomnia, and anxiety may occur, and if these symptoms worsen or suicidal thoughts arise, medical consultation should be sought immediately. Family members or caregivers should also closely observe changes in the patient's behavior. This medication may be affected by liver and kidney function, so patients with liver or kidney disease should consult their physician before use, and monitoring during treatment is necessary. Women who are pregnant or planning to become pregnant should consult their physician before taking this medication, and it is advisable not to take this medication while breastfeeding. Taking this medication with alcohol may increase the risk of side effects; thus, consumption of alcohol should be avoided or minimized during treatment. Exercise caution when performing tasks that require alertness, such as driving or operating machinery, as this medication may affect performance. Overdose may lead to severe side effects, such as seizures and loss of consciousness, so strict adherence to dosage is required, and immediate emergency treatment should be sought in case of overdose. Lastly, this medication should be kept out of the reach of children, and it is safe not to transfer it to other containers.

suicidal thoughts, suicidal ideation, suicide attempt, depression, hostility, aggression, anger, depressed mood, restlessness, behavioral changes, seizures, headache, infections, abdominal pain, fatigue, chest pain, pain, fever, palpitations, flushing, tachycardia, hypertension, orthostatic hypotension, vasodilation, syncope, hypotension, abnormal dreams, memory impairment, altered sensation, insomnia, dizziness, restlessness, anxiety, agitation, tremors, attention deficit, confusion, delusions, paranoid thinking, hallucinations, irritability, seizures, depersonalization, Parkinsonism, dystonia, ataxia, spasms, inability to cooperate, loss of appetite, blood sugar disorders, weight loss, hyponatremia, thirst, nausea, constipation, diarrhea, oral ulcers, thirst, elevated liver enzyme levels, jaundice, hepatitis, rash, itching, urticaria, angioedema, dyspnea, bronchospasm, anaphylactic shock, arthralgia, myalgia, taste disturbances, tinnitus, visual impairment, polyuria, urinary retention, fever, fatigue, malaise, facial edema, musculoskeletal chest pain, photosensitivity, chills, migraine, flashes, dysphagia, vomiting, spasms, drowsiness, hypersensitivity, memory decline, sensory disturbances, central nervous system excitation, pharyngitis, sinusitis, increased cough, sweating, tachycardia, vasodilation, stroke, syncope, complete heart block, extrasystole, myocardial infarction, phlebitis, pulmonary edema, bruxism, gastroesophageal reflux, gingivitis, glossitis, increased salivation, tongue edema, colitis, esophagitis, gastrointestinal bleeding, gingival bleeding, liver damage, pancreatitis, gastric ulcer, leg cramps, muscle rigidity, rhabdomyolysis, muscle weakness, abnormal cooperation, decreased libido, discomfort, emotional instability, hyperactivity, excessive muscle tension, sensory loss, suicide, dizziness, memory loss, ataxia, unreality, hypomania, electroencephalography abnormalities, inability to move, aggression, aphasia, coma, delirium, dysarthria, movement disorders, feelings of well-being, extrapyramidal syndrome, decreased movement, increased libido, manic response, neuralgia, neuropathy, paranoid thinking, suicide attempt, tardive dyskinesia, bronchospasm, pneumonia, erectile dysfunction, polyuria, prostate disorders, ejaculation abnormalities, cystitis, dyspareunia, dysuria, gynecomastia, menopause, pain during erection, salpingitis, incontinence, urinary retention, vaginitis, hyperglycemia, hypoglycemia, inappropriate antidiuretic hormone symptoms, edema, peripheral edema, diabetes, petechiae, anemia, leukocytosis, leukopenia, lymphadenopathy, pancytopenia, thrombocytopenia, bleeding, thromboembolic complications, papular rash, alopecia, angioedema, exfoliative dermatitis, hirsutism, pupillary control disturbances, dry eyes, hearing loss, diplopia, elevated intraocular pressure, mydriasis, insomnia, headache, dizziness, nausea, anxiety, restlessness, rash, vomiting, chest pain, dyspnea, pharyngitis, visual impairment, weight loss, schizophrenic response, Parkinsonism, depersonalization, pancreatitis, post-traumatic intracranial injury sequelae, fractures, prostate abnormalities, drowsiness, schizophrenic response, communication disorders, increased sputum, hemoptysis, sleep apnea, skin conditions, dermatitis, decreased urine flow, cerebral hemorrhage, bipolar disorder, pneumonia, alcohol addiction

This medication is sensitive to light and should be stored in a container that does not allow light to enter. It is also important to keep it in a cool place below 25 degrees Celsius to maintain its effectiveness.

Appearance

A white, round, film-coated tablet that is convex on both sides

Package unit

28 tablets (14 tablets/PTP × 2)