Diapolmin Tablets 250mg (Metformin Hydrochloride)

Adult dosage

The dosing should be based on individual drug response and tolerance and should not exceed the recommended maximum daily dose. It is recommended to start at a low dose; typically, it is administered 500 mg 2-3 times daily with meals. The dosage can be gradually increased by 500 mg weekly, and if taking 2000 mg, it is usually given twice daily in the morning and evening. If exceeding 2000 mg, it may be divided into three doses taken with meals, with a maximum daily dosage of 2550 mg. To determine the therapeutic response and minimum effective dose upon initiation and dosage adjustments, fasting blood glucose should be measured. Blood levels of glycated hemoglobin should be checked approximately every three months. The treatment goal for this medication, whether used alone or in combination with sulfonylureas or insulin, is to reduce fasting blood glucose and glycated hemoglobin levels to normal or near-normal levels with minimal effective doses. In general, when a patient's blood glucose is temporarily difficult to control with diet alone, sufficient efficacy can be achieved by a short-term use of this medication. Pediatric and adolescent use This medication can be used for children aged 10 years or older or adolescents. The usual initial dose is 500 mg once daily, taken during or after a meal. Blood glucose levels should be measured after one week to adjust the dosage. Gastrointestinal side effects can improve with gradual dose increases. The maximum daily dosage is 2000 mg, which is divided into 2-3 doses.

Children's dosage

Can be used for children aged 10 years or older or adolescents. The usual initial dose is 500 mg once daily, taken during or after a meal. Blood glucose levels should be measured after one week to adjust the dosage.

This medication can cause severe lactic acidosis or hypoglycemia; caution is needed. It should not be administered to patients with moderate to severe renal impairment or those in acute conditions such as dehydration, severe infections, or acute myocardial infarction. It is also contraindicated in patients with acute and unstable heart failure, patients undergoing radiographic procedures with iodinated contrast agents, and those who have hypersensitivity to this medication or other biguanides. It should not be given to patients with type 1 diabetes, diabetic ketoacidosis, or pre-comatose patients. In cases of serious infections, severe traumatic systemic disorders, patients pre- and post-surgery, malnutrition, starvation, or frailty, temporary discontinuation of this medication may be necessary. Patients with hepatic dysfunction, pulmonary embolism, severe pulmonary dysfunction, or excessive alcohol consumption should avoid this medication. When taking this medication, irregular meals, intense exercise, and concurrent medications may increase the risk of lactic acidosis and hypoglycemia; therefore, it should be used with caution. Lactic acidosis is a rare but very serious side effect; if symptoms such as muscle pain, difficulty in breathing, fatigue, or abdominal pain appear, it is essential to consult a physician immediately. Gastrointestinal symptoms such as diarrhea, nausea, and vomiting may commonly occur during early treatment, which can be alleviated by taking it with meals or adjusting the dosage. Hypoglycemia is rare with monotherapy but can occur when used in combination with other hypoglycemic agents or with insufficient food intake, requiring careful monitoring. This medication is excreted through the kidneys, so renal function should be regularly monitored; if renal function declines, the medication dosage should be reduced or stopped. Alcohol can affect the lactate metabolism of this medication, increasing the risk of lactic acidosis, so excessive drinking should be avoided during treatment. During pregnancy, since it crosses the placenta, it should be used cautiously according to the mother's condition, with close monitoring of fetal growth. In breastfeeding mothers, since this medication may be excreted in breast milk, careful consideration should be given to whether to continue breastfeeding or discontinue the medication during treatment. Elderly patients are at higher risk of renal function impairment, so dosage adjustments and regular renal function tests are required. In cases of overdose, the medication can be removed through hemodialysis; therefore, immediate medical attention is needed. This medication may interact with several other medications, so if other medications are being taken, the healthcare provider should be informed. Blood glucose control should be regularly checked, and if abnormal symptoms arise, immediate consultation with healthcare personnel is necessary. This medication does not cause weight gain, making it advantageous for diabetes patients requiring weight management. When administered to children or adolescents, it shows similar efficacy and safety as in adults, but special caution is needed.

Serious side effects

Lactic acidosis, severe allergic reactions (hives, severe swelling), severe skin reactions (severe rash, blisters, skin peeling, mucous membrane pain in mouth/eyes), respiratory problems (difficulty breathing, dyspnea), liver abnormalities (jaundice, malaise), severe neurological symptoms (severe headache, seizures, confusion, vision problems, paralysis), severe edema or urination abnormalities (decreased urine output, severe generalized edema,

Mild side effects

Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain), metallic taste, rash, anemia, leukopenia, thrombocytopenia, vitamin B12 deficiency, liver function abnormalities, hypoglycemia, delayed hypoglycemia

This medication should be stored in a tightly closed container to prevent exposure to air and moisture. It is best to maintain a storage temperature between 1°C and 30°C.

Appearance

White round film-coated tablet

Package unit

500 tablets/bottle