Ceftriaxone Injection 1g (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children aged 12 and older: administer 1-2 g (potency) of ceftriaxone as an intravenous or intramuscular injection once daily. For severe or moderately sensitive pathogen infections, the dose can be increased to 4 g (potency) once daily. For the treatment of gonorrhea, a single intramuscular injection of 250 mg (potency) is recommended. For preventing postoperative infections, administer 1-2 g (potency) depending on the risk of infection, 30-90 minutes before surgery.

Child administration

Neonates (up to 14 days old): administer 20-50 mg (potency) per kg of body weight once daily, not exceeding 50 mg (potency) per kg. Infants and children (15 days to 12 years):

This medication must not be mixed or administered concurrently with solutions containing calcium or other medications. Particularly in neonates, there is a risk of precipitation when calcium and this medication are combined, so it should not be administered. Patients allergic to this medication or with hypersensitivity to cephalosporin or penicillin antibiotics should not use it, and it should not be administered to premature infants and neonates with bilirubin binding impairment. Those with a history of drug allergies, individuals with severely impaired kidney function, elderly patients, and patients in poor general condition should use this medication with caution. This medication can cause various side effects primarily in blood, digestive system, skin, liver, and kidneys, so symptoms should be closely monitored during administration. If severe allergic reactions or shock symptoms occur, treatment should be immediately discontinued, and appropriate emergency measures should be taken. This medication should be used only for the necessary duration to prevent resistance; it is advisable to check for allergies before administration. During treatment, regular assessments of liver and kidney function and blood tests should be conducted. There is no specific antidote for overdose, so symptomatic treatment should be provided. Caution is advised when driving or operating machinery, as side effects like dizziness may occur. Women who are pregnant or breastfeeding should consult a doctor before using this medication, as it may affect the fetus or neonate. It is safer not to administer this medication to children, particularly neonates and premature infants, as it may increase the risk of bilirubin encephalopathy. Elderly patients may experience side effects more easily due to decreased bodily functions, so administration should be done carefully regarding dosage and intervals. This medication can interact with other drugs, so caution is needed, especially when used with diuretics or aminoglycoside antibiotics that may affect the kidneys. When administering, do not inject simultaneously with calcium-containing solutions; ensure to separate the injection ports or thoroughly wash them before administration in sequence. Prepared solutions should be used as soon as possible, and it is advisable not to store them for excessive periods.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attacks, abnormal breathing accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headaches, thunderclap headaches, seizures, altered consciousness, visual disturbances, paralysis, urination issues

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to prevent air or moisture ingress and should ideally be kept at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's efficacy.

Appearance

White to pale yellow crystalline powder filled in a colorless, transparent vial

Package unit

1 vial, 10 vials