Lamocillin Tablet 625 mg (Amoxicillin, Clavulanate Potassium)

Adult dose

For adults and children over 12 years of age or weighing over 40 kg, the dosage is 250 mg/125 mg of amoxicillin/clavulanate potassium, taken orally three times a day at 8-hour intervals. In cases of severe and respiratory infections, the dosage may be increased to 500 mg/125 mg at a time. In cases of renal impairment, the dose should be adjusted according to creatinine clearance. - Creatinine clearance 10 ～ 30 mL/min: Amoxicillin 250 mg.

Child dose

For children under 12 years of age or weighing less than 40 kg, dosing should be reduced accordingly.

This drug is a beta-lactam antibiotic and must not be used in patients with a history of hypersensitivity to penicillins or cephalosporins. Caution is needed especially in cases with a history of severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, and shock. It should be avoided in patients with viral infections such as infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with a history of liver dysfunction or jaundice from this medication or penicillin should refrain from use due to a potential risk of recurrence. Patients with impaired liver or kidney function may have increased drug concentration, necessitating dose adjustments and careful monitoring. Attention should be paid to allergy-prone individuals, the elderly, and those with poor nutritional status, as vitamin deficiency symptoms may arise. Gastrointestinal symptoms such as abdominal pain, diarrhea, and vomiting may occur, and especially if severe colitis symptoms such as pseudomembranous colitis arise, administration should be discontinued immediately. Liver function must be carefully monitored during and after treatment as hepatitis or jaundice may arise from liver dysfunction. Severe skin reactions such as rashes, urticaria, and in severe cases, Stevens-Johnson syndrome may occur; if these symptoms arise, administration should be stopped immediately and medical advice followed. Blood abnormalities such as leukopenia and thrombocytopenia have been reported infrequently, which may require regular blood testing. Central nervous system symptoms such as anxiety, agitation, confusion, and seizures may occur infrequently, particularly in cases of impaired kidney function or high-dose administration. Kidney issues such as deterioration of kidney function and acute renal failure may occur, so regular kidney function tests are recommended. Antibiotic use may disrupt gut bacterial balance, leading to candidiasis or stomatitis, which should be treated appropriately if symptoms arise. There may be a tendency for bleeding due to vitamin K deficiency, so attention to bleeding symptoms is required. This medication may interact with other drugs; extra caution is needed when combined with anticoagulants, probenecid, allopurinol, or mycophenolate mofetil. It is best not to use during the first trimester of pregnancy, and during breastfeeding, the baby should be monitored for diarrhea or skin rash as adverse reactions may occur. It is recommended for children over 12 years old or weighing over 40 kg, and cautious administration is necessary in the elderly due to an increased risk of adverse reactions from diminished physiological function. In case of overdose, gastrointestinal symptoms, seizures, and hypersensitivity shock may occur; administration should be stopped immediately and appropriate emergency care sought. This medication should be stored in a dry place at or below 25 degrees Celsius, and regular monitoring for resistance bacteria and liver, kidney, and hematologic function is necessary during prolonged use.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever accompanied by severe rashes, blisters, skin peeling, pain in mouth/eyes, severe skin reactions, asthma attacks, respiratory distress accompanied by cough and fever, shortness of breath or difficulties breathing, liver abnormalities (jaundice), yellowing of skin or eyes, extreme lethargy, sudden and very severe headaches,

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, anorexia, abdominal pain, abdominal distension, constipation, colonic pain, acid reflux, soft stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-induced colitis, blood in stools, itching, erythema multiforme, angioedema, serum sickness symptoms (fever, rash, joint pain, swelling, lymphadenopathy), eosinophilia, systemic symptoms, acute generalized exanthematous pustulosis, blood system abnormalities

This medication should be stored in a closed container to prevent moisture intrusion and kept in a dry place at or below 25 degrees Celsius. This will help maintain the drug's effectiveness for a longer period.

Appearance

White or almost white oval film-coated tablets

Package unit

40 tablets/PTP