Rosuvastatin Calcium 20 mg Tablet

Adult dosage

The initial dose is 5 mg once daily, and if greater reduction of LDL cholesterol is needed, the maintenance dose can be adjusted. The maintenance dose is usually 10 mg once daily, and most patients are managed at this dose. The maintenance dose should be adjusted adequately based on LDL cholesterol levels, treatment goals, and patient response, with a maximum daily dosage of 20 mg.

This medication should not be used in certain patients. For example, individuals who are allergic to this medication, those with active liver disease, muscle disorders, and patients with severe renal impairment should not take this drug. Women who are pregnant or breastfeeding should not use this medication, and women of childbearing potential should use appropriate contraceptive methods to minimize the possibility of pregnancy. Moreover, patients at high risk for muscle disorders should avoid high doses. This drug contains lactose, so caution is required for patients with lactose intolerance. Patients with poor liver function or excessive alcohol intake should have regular liver function tests before and during treatment with this medication. Those with thyroid dysfunction or nephrotic syndrome should treat their underlying conditions before taking this drug. Muscle-related side effects such as myalgia, myopathy, and rhabdomyolysis have been reported; thus, if there are any unusual muscle symptoms, immediate medical consultation is necessary. Particularly, if muscle pain, weakness, or cramps occur, blood tests should be performed to check for muscle damage, and discontinuation of the medication may be warranted if necessary. This medication can interact with certain drugs; therefore, if other drugs are being taken, healthcare providers should be informed. Particularly, co-administration with drugs that affect hepatic metabolism may increase the blood concentration of this drug, raising the risk of side effects. The safety of this medication has not been established in pregnant or breastfeeding women; hence, its use should be avoided, and women planning to become pregnant should consult their healthcare provider prior to use. There is no specific antidote for overdose; management should focus on symptomatic treatment along with liver function and muscle enzyme tests. This medication is known not to significantly affect the ability to drive or operate machinery, but caution is required as symptoms such as dizziness may occur. Finally, if severe skin reactions or allergic symptoms appear during treatment with this medication, it should be discontinued immediately and healthcare providers should be consulted.

Serious side effects

Allergic reactions including urticaria and angioedema, pancreatitis, myopathy (including myositis), rhabdomyolysis, polyneuropathy, amnesia, peripheral neuropathy, severe muscle weakness, dyspnea, ophthalmoplegia, thrombocytopenia, jaundice, hepatitis, Stevens-Johnson syndrome, eosinophilia, and systemic symptom accompanied drug reaction syndrome (DRESS), immune-mediated necrotizing myopathy, acute kidney injury, oliguria, increased serum creatinine levels.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and light, and it is best stored at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness and prevent degradation.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle