Simvazet Tablet 10/10

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg per day, and the generally recommended starting dose is 10/20 mg per day. Patients who require less reduction of LDL cholesterol may start at 10/10 mg per day. After starting treatment or adjusting the dosage, serum lipid levels should be checked after an interval of more than 4 weeks.

This medication can cause serious muscle-related side effects such as myopathy and rhabdomyolysis. The risk of these side effects may increase especially when taken in high doses or in combination with certain medications. Patients with hypersensitivity to the components of this medication or active liver disease, as well as women who are pregnant or nursing, should not take it. Additionally, patients taking strong CYP3A4 inhibitors, gemfibrozil, cyclosporine, or danazol should also avoid this medication. Caution is advised for patients with severe myasthenia gravis or ocular myasthenia gravis, and if symptoms such as myalgia, tenderness, or muscle weakness appear during use, consult a physician immediately. Patients with liver dysfunction should also be monitored carefully, and treatment should be discontinued if liver function tests consistently show abnormalities. During the course of this medication, do not take other medications without consulting a physician, and when prescribed new medications, it is essential to inform the physician that this medication is being taken. Women who are planning to become pregnant or may be pregnant should consult a physician before taking this medication and must discontinue use immediately if pregnancy is confirmed. It is also safest for nursing women to discontinue breastfeeding while on this medication. Elderly patients, especially those over 65, may respond more sensitively to this medication, hence caution is needed while using it. Additionally, this medication may raise blood sugar levels, so patients at risk for diabetes should check their blood sugar regularly. In the event of overdose, there is no specific antidote, so symptomatic treatment should be received, and regular check-ups and monitoring are crucial to prevent and manage side effects.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, skin peeling, pain in mucous membranes of mouth/eyes, breathing difficulties, asthma attacks, abnormal breathing accompanied by cough and fever, yellowing of skin or eyes (jaundice), profound lethargy, sudden and severe headache, thunderclap headache, seizure, confusion, vision disturbances, paralysis, urination

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• myalgia
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This medication is sensitive to air and humidity, so it must be stored in a tightly sealed container. Additionally, avoid storing it in extremely hot or cold places and store it at room temperature between 1°C and 30°C.

Appearance

White to pale yellow, bilaterally convex rectangular tablet

Package unit

30 tablets/Alu-Alu packaging (10 tablets/Alu-Alu * 3)