Famciclovir Tablets 250 Milligrams (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally three times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer this medication 250 mg orally three times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medication 125 mg orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medication 250 mg orally twice daily. Interrupt treatment periodically every 6～12 months to observe whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the clearance of this medication is reduced in patients with renal impairment, dosage adjustment should be undertaken with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following formulas. Men: {weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours, taking the dialysis interval into account, is preferable. Since 4 hours of hemodialysis reduces the plasma concentration of this medication by about 75%, administer this medication immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is required for patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a specific recommended dose has not been established.

This medicine should not be used by patients who have had allergic reactions to this medicine or its components. Furthermore, as this medicine contains lactose, it should not be administered to patients who have a hereditary intolerance to lactose. Care should be taken when using this medicine in patients with impaired kidney function, and dosage adjustments may be necessary. Patients should be cautious as symptoms such as headache, nausea, dizziness, and drowsiness may occur during treatment. If severe skin rashes, edema, liver dysfunction, or blood abnormalities occur, patients should consult a doctor immediately. This medication cannot cure genital herpes; thus, it is essential to avoid sexual intercourse during treatment if symptoms persist and to practice safe sex. If dizziness or drowsiness occurs during treatment, patients should refrain from driving or operating machinery. Extreme caution is needed in patients with severely impaired liver function as the efficacy may be reduced. This medication generally has low interaction with other drugs, but should be discussed with a doctor or pharmacist when used with specific medications as blood concentrations may change. Women who are pregnant or breastfeeding should consult a doctor before using this medicine and should only be prescribed if the benefits outweigh the risks. It is advisable not to use this medicine in children under 18, as safety and efficacy have not been established. Generally, no dosage adjustment is necessary for the elderly, but dosage should be adjusted if kidney function is impaired. In case of overdose, seek immediate medical attention for appropriate treatment; the active ingredient can be removed through dialysis. This medicine should be stored in a dry place below 30 degrees Celsius, away from children's reach. Additionally, caution should be exercised as transferring to another container may affect its quality.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medicine should be kept in a sealed container to protect it from air and moisture. It is recommended to store it in a cool, dry place below 30 degrees Celsius.

Appearance

White, round, film-coated tablet

Package unit

21 tablets/bottle