Seroquel 200 mg (Quetiapine Fumarate)

Adult dose

1. Schizophrenia Adults: This medication is taken twice daily, regardless of meals. The total daily dose for the first 4 days is 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4. From Day 4 onward, adjust the dose to the usual effective daily dose of 300～400 mg. The dose may be adjusted within the range of 150～750 mg/day according to the clinical response and tolerability of each patient. 2. Bipolar disorder (1) Acute treatment of manic episodes associated with bipolar I disorder: Adults: This medication is taken twice daily, regardless of meals. As monotherapy or as adjunctive therapy to a mood stabilizer (lithium or valproate), the total daily dose for the first 4 days is 100 mg on Day 1, 200 mg on Day 2, 300 mg on Day 3, and 400 mg on Day 4. The total daily dose may be increased to 800 mg by Day 6, in increments of no more than 200 mg per day. The dose may be adjusted within the range of 200～800 mg/day according to the clinical response and tolerability of each patient; the usual effective daily dose is 400～800 mg. (2) Treatment of depression associated with bipolar disorder: Adults: This medication is taken once daily at bedtime, regardless of meals. The total daily dose for the first 4 days should reach 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, and 300 mg on Day 4. In confirmatory clinical trials of this medication, doses of 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3, 300 mg on Day 4, 400 mg on Day 5, and up to 600 mg on Day 8 were administered. The recommended daily dose is 300 mg. Antidepressant effects were observed with both 300 mg and 600 mg, but there was no additional benefit with 600 mg. Increases above 300 mg should be initiated by a physician experienced in treating bipolar disorder. In patients who tolerate the medication, clinical trials have shown that the dose may be reduced to a minimum of 200 mg. (3) Prevention of recurrence of bipolar disorder: Adults: To prevent recurrence of manic, mixed, or depressive episodes associated with bipolar disorder, patients who responded to quetiapine for acute treatment of bipolar disorder should continue on the same dose. Depending on clinical response and individual tolerability, the dose may be adjusted within the range of 300～800 mg/day, administered twice daily. It is important to use the minimum effective dose for maintenance therapy. 3. Elderly patients: For elderly patients, start this medication at 25 mg/day and gradually increase by 25～50 mg/day. The effective dose in elderly patients may be lower than that in younger patients. 5. Patients with renal or hepatic impairment: For patients with renal or hepatic impairment, start this medication at 25 mg/day and gradually increase by 25～50 mg/day to the effective dose.

Child dose

4. Children and adolescents: The safety and efficacy of this medication have not been established in children and adolescents.

This medication may increase the risk of suicidal thoughts or behavior in children, adolescents, and young adults with major depressive disorder or psychiatric disorders, necessitating careful judgment by the physician. Additionally, this medication can raise blood sugar levels, potentially worsening diabetes symptoms; therefore, patients with diabetes or risk factors should regularly monitor their blood sugar and observe symptoms carefully. Neuroleptic Malignant Syndrome, a serious adverse effect, may occur rarely, and if symptoms such as high fever, muscle rigidity, or changes in consciousness present, immediate medical attention is necessary. Long-term use may lead to movement disorders like extrapyramidal symptoms or tardive dyskinesia, thus dose adjustment or discontinuation should be considered if symptoms arise. Elderly patients with dementia may have an increased risk of mortality, hence its use is not recommended. Severe neutropenia or agranulocytosis can occur, thus regular checking of white blood cell counts and immediate treatment for any signs of infection are needed. Special caution is required for patients at high risk of cerebrovascular disease or venous thromboembolism, and those with cardiovascular diseases or hypotension should be administered with care. This drug can induce severe skin reactions, so if symptoms like rash, fever, or lymphadenopathy occur, discontinuation and immediate consultation with healthcare professionals are required. For pregnant or nursing mothers, this medication should only be used if necessary due to potential effects on the fetus or newborn, and nursing should be avoided while on this medication. Common side effects may include drowsiness, dizziness, dry mouth, weight gain, thus caution is advised while driving or operating machinery. Sudden discontinuation can lead to withdrawal symptoms, hence it should be tapered according to physician's instructions. Interactions with other medications may occur, so it is crucial to inform your doctor or pharmacist of any other medications being taken.

Drowsiness, dizziness, dry mouth, withdrawal symptoms, increased triglyceride levels, increased total cholesterol, decreased HDL cholesterol, weight gain, decreased hemoglobin, extrapyramidal symptoms, fainting, neuroleptic malignant syndrome, leukopenia, neutropenia, peripheral edema, speech disorder, seizures, restless legs syndrome, tardive dyskinesia, nightmares, symptoms related to sleepwalking, constipation, dyspepsia, vomiting, difficulty swallowing, intestinal obstruction, bowel obstruction, difficulty breathing, rhinitis, tachycardia, palpitations, bradycardia, cardiomyopathy, myocarditis, orthostatic hypotension, hypertension, hypersensitivity reactions, anaphylactic reactions, blurred vision, pain in the back, myalgia, rhabdomyolysis, priapism, galactorrhea, increased appetite, mild muscular weakness, peripheral edema, chest pain, irritability, fever, hypothermia, neonatal withdrawal symptoms, increased serum triglycerides, increased serum liver enzymes, increased eosinophils, elevated blood sugar levels, increased serum prolactin, thrombocytopenia, increased serum creatine phosphokinase, agranulocytosis, hepatitis, liver failure, urinary retention, urinary disorders, incontinence, abnormal ejaculation, erectile dysfunction, lethargy, increased CK levels, increased sweating, weight loss, hyperkalemia, tongue paralysis, sensory impairment, obesity, edema, facial flushing, toothache, facial edema, neck stiffness, skin nodules, pelvic pain, dental diseases, gout, arthralgia, osteoarthritis, bursitis, myasthenia, spasms, exacerbation reactions, accidental injury, ear diseases, taste disturbances, acne, insomnia, anxiety, nervousness, headache, hallucinations, forgetfulness, aggressive reactions, confusion, neurosis, delusions, hypersexuality, emotional instability, agitation, confusion, abnormal thinking, increased suicidal tendencies, personality disorder, manic reactions, euphoria, chorea and athetosis, migraines, depressive reactions, monologues, impulsive behavior, automatic movements, schizoaffective reactions, ataxia, mental confusion, hostility, inability to sit still, forward motion, muscle rigidity, salivation, bradykinesia, gait abnormalities, movement disorders, dystonia, abnormal eye movements, slow movements, thrombosis, pulmonary embolism, venous thrombosis, thromboembolism, increased risk of suicidal tendencies, paralytic ileus, acute renal failure due to rhabdomyolysis, suicidal impulses and behavior, hostility, aggression, anger, suicidal tendencies, suicide attempts, increased risk of suicidal tendencies

This medication should be kept in a tightly sealed container to prevent air or moisture from entering. Additionally, it is important to maintain a cool temperature below 30 degrees Celsius when storing the medication.

Appearance

White circular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle