Clarithromycin Tablets (Clarithromycin)

Adult dosage

○ Adults: The usual dose is clarithromycin 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this medication twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medication three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This drug should not be used in patients who have hypersensitivity to additives or macrolide antibiotics. Serious side effects such as cardiac arrhythmias can occur with certain drugs, therefore combinations should be avoided. It should not be administered to patients with severe liver or kidney dysfunction, or to pregnant or breastfeeding women. Patients with central nervous system infections or those on specific medications should also avoid using this drug. Patients with impaired liver function or reduced kidney function should use this medication cautiously, and dosage adjustments may be necessary. This drug may rarely cause allergic reactions, gastrointestinal disturbances, respiratory issues, blood abnormalities, neurological issues, liver dysfunction, or skin reactions. If severe allergic reactions or skin conditions occur, use should be stopped immediately, and appropriate treatment should be obtained. Antibiotic-associated pseudomembranous colitis or diarrhea may occur, so if diarrhea persists, healthcare professionals should be informed. This medication has numerous drug interactions, so inform a doctor or pharmacist about any other medications being taken, as some cannot be combined. Pregnant or breastfeeding women should not use this medication, and if necessary, breastfeeding should be discontinued. Elderly patients should use this drug carefully due to potential increased drug concentrations from reduced kidney function. This medication is not recommended for children under 12 years old, and syrup use is limited for infants under 6 months. In case of overdose, gastrointestinal symptoms and central nervous system issues may occur, and immediate medical assistance should be sought. During the course of this treatment, one should be cautious about dizziness or confusion when driving or operating machinery. The treatment duration and dosage should strictly follow medical advice to prevent antibiotic resistance, and it should only be taken for the necessary duration.

Shock, Anaphylactic symptoms, Respiratory distress, Convulsions, Flushing, Rash, Itching, Hives, Skin flushing, Angioedema, Joint swelling, Drug rash, Abdominal distension, Nausea, Vomiting, Dyspepsia, Abdominal pain, Discomfort, Flatulence, Diarrhea, Oral mucosal erosion, Upper abdominal pain, Thirst, Teeth discoloration, Pancreatitis, Increased amylase, Dysgeusia, Anorexia, Constipation, Changes in stool color, Pseudomembranous colitis, Hemorrhagic colitis, Fever, Cough, Abnormal chest X-ray, Eosinophilia, Eosinophilic pulmonary infiltration, Interstitial pneumonia, Chronic bronchitis, Acute exacerbation of maxillary sinusitis, Eosinophilia, Thrombocytopenia, Pancytopenia, Hemolytic anemia, Leukopenia, Agranulocytosis, Dizziness, Depression, Loss of taste, Loss of smell, Anxiety, Insomnia, Nightmares, Tinnitus, Confusion, Disorientation, Hallucinations, Psychosis, Depersonalization, Convulsions, Tremors, Numbness, Behavioral changes, Manic behavior, Stevens-Johnson syndrome, Toxic epidermal necrolysis, Allergic purpura, Drug rash (DRESS), Jaundice, Hepatocellular hepatitis, Cholestatic hepatitis, Increased liver enzyme levels, Liver dysfunction, Liver failure, Fulminant hepatitis, Elevated AST, Elevated ALT, Increased γ-GTP, Elevated LDH, Increased ALP, Elevated total bilirubin, Anorexia, Jaundice, Dark urine, Pruritus, Abdominal tenderness, Elevated serum creatinine, Increased BUN, Interstitial nephritis, Renal failure, Rhabdomyolysis, Myalgia, Weakness, Elevated CPK, Increased serum myoglobin, Elevated urinary myoglobin, Glossitis, Stomatitis, Oral candidiasis, QT prolongation, Ventricular tachycardia, Torsades de pointes, Fatigue, Headache, Dysgeusia, Hearing loss, Dysesthesia, Arthralgia, Myalgia, Olfactory dysfunction, Tinnitus, Hearing impairment, Hypoglycemia, Rhabdomyolysis, Purpuric rash, Acute generalized exanthematous pustulosis, Muscle spasms, Musculoskeletal stiffness, Myopathy, Elevated serum creatinine, Elevated blood urea nitrogen, Renal failure, Nephritis, Venous thrombophlebitis at injection site, Injection site pain, Injection site inflammation, Fever, Asthenia, Chest pain, Chills, Fatigue, Abnormal albumin-globulin ratio, Increased alkaline phosphatase, Elevated lactate dehydrogenase, Increased INR, Prothrombin time prolongation, Abnormal urine color, Cardiac arrest, Atrial fibrillation, ECG QT prolongation, Ectopic beats, Palpitations, Vasodilation, Asthma, Epistaxis, Pulmonary embolism, Esophagitis, Gastroesophageal reflux disease, Gastritis, Rectal pain, Belching, Abdominal distension, Tongue discoloration, Hyperhidrosis, Papular rash, Acne, Henoch-Schonlein purpura

This drug is sensitive to light and should be stored in a tightly sealed container that blocks light. It is recommended to maintain a storage temperature between 15 and 30 degrees Celsius.

Appearance

Yellow oval film-coated tablets

Package unit

Bottle - 30 tablets/bottle, Bottle - 200 tablets/bottle