Gabrick 80mg (Febuxostat)

Adult dosage

1. Adults This medicine is administered at a dose of 40mg or 80mg once daily, regardless of meals. This medicine acts very rapidly; therefore, recheck the serum uric acid concentration after 2 weeks. The treatment goal is to lower and maintain the serum uric acid concentration below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance below 30mL/min). 3. Patients with hepatic impairment No specific dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular death when administered to patients with cardiovascular diseases; therefore, it is advisable for patients with a history of major cardiovascular diseases such as myocardial infarction, stroke, or unstable angina to avoid this medication if alternative treatments are available. Patients allergic to this medication's active ingredient or excipients, those taking specific drugs like mercaptopurine or azathioprine, and those with lactose intolerance or specific genetic metabolic disorders should not take this medication. Patients with liver diseases or abnormal thyroid function, as well as those with ischemic heart disease or congestive heart failure, should undergo regular liver function tests and thyroid function tests while taking this medication, and caution is required when combined with certain drugs. Various side effects such as liver dysfunction, diarrhea, headache, rash, fatigue, muscle pain, and dizziness may occur during the use of this medication, and if these symptoms arise, immediate consultation with healthcare professionals is necessary. This medication should not be initiated during an acute gout attack, and it is recommended to use other medications to prevent worsening of gout symptoms during the initial administration period. It is safer for pregnant or breastfeeding women not to take this medication, and it has not been studied in pediatric patients under 18 years of age, thus avoiding use in this population. In case of overdose, there is no specific antidote, so symptomatic treatment will be provided. This medication should be kept out of reach of children and does not require special storage conditions. While taking this medication, monitor carefully for any cardiovascular symptoms and discontinue treatment and seek testing immediately if signs of liver dysfunction appear. Additionally, this medication can interact with other drugs, so it is crucial to inform healthcare professionals of any concomitant medications, especially avoiding co-administration with mercaptopurine or azathioprine.

Abnormal liver function, nausea, arthralgia, rash, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, electrocardiogram abnormalities, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, dizziness, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, bloating, increased bowel movements, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, hyperchlorhydria, hematochezia, oral ulcers, pancreatitis, gastric ulcer, vomiting, asthenia, chest pain, chest discomfort, edema, fatigue, mood disturbances, gait disorders, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes mellitus, hepatic steatosis, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle single contraction, muscle tightness, muscle weakness, musculoskeletal pain, muscle rigidity, myalgia, pruritus, dyspnea, taste changes, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, olfactory impairment, heat-induced infarction, drowsiness, mental disorders, migraine, sensory disturbances, sleepiness, transient ischemic attack, tremors, agitation, anxiety, depression, insomnia, excitability, decreased libido, nervous hyperreactivity, panic attacks, personality changes, hematuria, nephrolithiasis, frequent urination, proteinuria, renal failure, renal insufficiency, urinary urgency, urinary incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, epistaxis, nasal dryness, excessive sinus secretions, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin eruptions, petechiae, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin peeling, petechial hemorrhages, photosensitivity, itching, purpura, skin discoloration, pigmentation changes, skin lesions, axillary osmidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, activated partial thromboplastin time prolongation, increased creatinine, decreased bicarbonate, increased sodium, EEG abnormalities, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased MCV, decreased red blood cells, increased creatinine, increased blood urea, increased blood urea nitrogen to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, increased urine output, decreased urine output, decreased lymphocyte count, decreased neutrophil count, increased white blood cell count, decreased white blood cell count, abnormal blood coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urinary leukocytes, positive urinary protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, eosinophilia, drug reaction with systemic symptoms, hepatic failure, jaundice, liver dysfunction, abnormal liver function, agranulocytosis, rhabdomyolysis

This medication should be stored in a sealed container to protect it from air and moisture. It is essential to maintain a storage temperature between 1 degree and 30 degrees Celsius. This will help preserve the effectiveness and safety of the medication.

Appearance

Light yellow to yellow oblong film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle