Crosin Film-Coated Tablets (Clarithromycin)

Adult dosage

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, reduce the dose by half: 250mg (potency) once daily, or 250mg (potency) twice daily for severe infections. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcer: Administer 500mg (potency) of this medicine 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) 3 times daily for 14 days (days 1~14) and omeprazole 40mg once daily for 28 days (days 1~28).

Children's dosage

Children 12 years of age and older: Same as adults. Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in certain patients. It should not be given to patients who are allergic to any of its ingredients or have had hypersensitivity to macrolide antibiotics. Additionally, patients with certain heart conditions or severely impaired liver or kidney function should not take this medication. Pregnant or breastfeeding women should also refrain from using this medicine. This drug can interact with other medications, so it is essential to inform your doctor of any other medicines currently being taken. This medication is excreted through the liver and kidneys, so it should be administered cautiously in patients with liver disease or moderate to severe renal insufficiency. Elderly patients or those with heart conditions should also take care when taking this drug. Furthermore, care should be taken when combining this medication with similar classes of antibiotics as resistant bacteria may develop. While taking this drug, severe allergic reactions, respiratory distress, arrhythmias, liver dysfunction, and decreased kidney function may rarely occur. If symptoms such as abdominal pain, diarrhea, skin rash, or dizziness arise, immediate consultation with a healthcare professional is necessary. Especially, persistent diarrhea or abdominal pain may indicate serious bowel conditions such as pseudomembranous colitis, thus caution is advised. This medication may alter blood concentration when taken with other drugs, so it is necessary to inform the doctor or pharmacist about any concurrent medications. Caution is particularly needed when combined with medications affecting the heart or those metabolized by the liver. Also, when used in combination with hypoglycemic agents or insulin, there is a risk of hypoglycemia, so blood sugar levels should be monitored closely. Pregnant or breastfeeding women should ideally avoid using this medication; if it is necessary to use, breastfeeding should be discontinued. The use of this medication in children may be restricted depending on age, so it's important to consult a professional before use. This medication may affect driving or machine operation, so caution is advised if symptoms such as dizziness or confusion occur. In case of overdose, gastrointestinal disturbances or neurological symptoms may arise; immediate medical attention should be sought for appropriate treatment. It is important to take this medication for only the necessary minimum duration to prevent the development of resistant bacteria. If any unusual symptoms occur during the course of treatment, administration should be stopped immediately and a healthcare professional consulted.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, pruritus, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, fecal discoloration, membrane colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrate, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, hepatic dysfunction, liver failure, fulminant hepatitis, increased AST, increased ALT, increased γ-GTP, increased LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, weakness, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, vomiting, petechial rash, intravenous site phlebitis, intravenous site pain, intravenous site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration

This medication should be stored in a sealed container to protect it from air and moisture. Additionally, it should be kept away from direct sunlight and stored in a dry place, with a suitable storage temperature between 1°C and 30°C.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets, 100 tablets