Abapent Capsule 300 mg (Gabapentin)

Adult dose

Monotherapy and adjunctive therapy for patients with epilepsy aged 13 years and older: To achieve a maintenance dose of 900 mg/day of gabapentin, titrate gradually over the first 3 days of treatment as follows. Day 1: Take one 300 mg capsule of this drug once daily, or one 100 mg capsule of this drug three times daily (gabapentin 300 mg/day) Day 2: Take one 300 mg capsule of this drug twice daily, or two 100 mg capsules of this drug three times daily (gabapentin 600 mg/day) From Day 3: Take one 300 mg capsule of this drug three times daily, or three 100 mg capsules of this drug three times daily (gabapentin 900 mg/day) Alternatively, one 300 mg capsule of this drug may be taken three times daily as the starting dose (gabapentin 900 mg/day). The dose may be increased to 1,200 mg/day of gabapentin; the total daily dose must not exceed 2,400 mg of gabapentin. (There are insufficient data on the safety and efficacy of doses exceeding 2,400 mg/day of gabapentin.) Adults with neuropathic pain (18 years and older): To achieve a maintenance dose of 900 mg/day of gabapentin, titrate gradually over the first 3 days of treatment as follows. Day 1: Take one 300 mg capsule of this drug once daily, or one 100 mg capsule of this drug three times daily (gabapentin 300 mg/day) Day 2: Take one 300 mg capsule of this drug twice daily, or two 100 mg capsules of this drug three times daily (gabapentin 600 mg/day) From Day 3: Take one 300 mg capsule of this drug three times daily, or three 100 mg capsules of this drug three times daily (gabapentin 900 mg/day) Alternatively, one 300 mg capsule of this drug may be taken three times daily as the starting dose (gabapentin 900 mg/day). If necessary, the dose may be increased to 1,800 mg/day of gabapentin within one week; the total daily dose must not exceed 3,600 mg of gabapentin. When taking this drug, the total daily dose should be divided into 3 doses. Frailty: In frail patients with low body weight or patients after transplant surgery, the gabapentin dose should be increased in 100 mg increments. Older adults: Dose adjustment may be required due to age-related decline in renal function (see table). Patients with renal impairment (creatinine clearance ≤80 mL/min) or patients receiving hemodialysis: Dose adjustment is required based on the following table. Dosage for patients with renal impairment: Renal function, creatinine clearance (mL/min) ≥80: Total daily dosea (mg/day) 900∼2,400 50∼79: 600∼1,800 30∼49: 300∼900 15∼29: 150b∼600 <15: 150b∼300 a: The total daily dose should be divided into 3 doses. b: Administer 3 × 100 mg every 2 days. For patients with creatinine clearance below 15 mL/min, the dose should be reduced in proportion to creatinine clearance. Dosage for patients on hemodialysis Initial dose: 300∼400 mg of gabapentin is recommended. Maintenance dose: Administer 200∼300 mg of gabapentin after 4 hours of hemodialysis; do not administer this drug on days when hemodialysis is not performed. This drug should be swallowed whole with plenty of fluid and may be taken with or without food. When administered 3 times daily, take care that the dosing interval does not exceed 12 hours to prevent recurrence of seizures. If a dose of this drug is missed (if more than 12 hours have elapsed since the last dose), whether to take an additional dose to make up for it should be determined by a physician. When used with antacids containing magnesium or aluminum, this drug should be taken at least 2 hours after the antacid. If treatment with this drug is to be discontinued, or if it is to be used concomitantly with another antiepileptic drug, the change should be made gradually over at least 1 week. The safety and efficacy of treatment for neuropathic pain for periods longer than 5 months have not been evaluated. To reduce the main adverse effects, such as somnolence, dizziness, fatigue, and ataxia, the first dose on the first day of treatment should be taken at bedtime.

Child dose

Adjunctive therapy in children aged 3 years to 12 years: To achieve a maintenance dose of gabapentin 30 mg/kg/day, titrate over the first 3 days of treatment as follows. Day 1: gabapentin 10 mg/kg body weight; Day 2: gabapentin 20 mg/kg body weight; from Day 3: gabapentin 30 mg/kg body weight. The dose may be increased as needed to a maximum of 40 mg/kg body weight per day. The total daily dose of this medicine should be divided into 3 doses.

This medication may increase the risk of suicidal thoughts or behavior, so if any changes in mood or behavior occur during treatment, inform your doctor immediately. Suddenly stopping this medication can lead to more frequent seizures or progression to status epilepticus; therefore, it must be tapered off gradually as directed by a physician. If symptoms of pancreatitis, such as persistent upper abdominal pain, nausea, or repeated vomiting occur, this medication should be stopped immediately and healthcare professionals should be consulted. Children aged 3 to 12 years taking this medication may exhibit neurological and psychiatric symptoms such as emotional instability, aggression, decreased concentration, and hyperactivity, so caution is advised. Taking this medication with central nervous system depressants, including opioids, may lead to severe drowsiness, respiratory depression, or coma; therefore, it should only be taken at the lowest effective dose for the shortest duration under close observation by healthcare professionals. This medication should not be administered to patients with hypersensitivity, acute pancreatitis, certain types of seizures, or those with hereditary lactose intolerance. Patients with impaired kidney function, elderly patients, children with a history of psychiatric conditions or attention deficit and behavioral disorders, pregnant or breastfeeding women should use this medication cautiously. Side effects may include dizziness, drowsiness, coordination problems, memory impairment, nausea, vomiting, which necessitates caution when driving or operating machinery. During pregnancy, especially in the early stages, this medication may affect the fetus, therefore its use during pregnancy should be decided in consultation with a healthcare provider, and effective contraception should be utilized by women who may become pregnant. This medication can be transferred into breast milk, so breastfeeding status should also be discussed with healthcare professionals. While taking this medication, it is important to regularly monitor weight and physical condition, and inform healthcare professionals immediately regarding any adverse reactions. Do not change the dosage of this medication arbitrarily, and take care not to exceed 12 hours between doses. Store out of reach of children, and keep in the original container to prevent misuse or degradation of quality.

• Suicidal thoughts
• suicidal behavior
• depression
• abnormal changes in mood and behavior
• hemorrhagic pancreatitis
• emotional instability
• hostility
• thought disorder
• hyperactivity
• weakness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and the storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature. This is an important storage method to maintain the drug's effectiveness and prevent deterioration.

Appearance

Light yellow hard capsule filled with white or grayish powder

Package unit

30 capsules, 300 capsules