Medication info

CDSA Solution 0.1%

Prescription medication주사
Ingredient · strength
Sodium Chloride›Strength being verifiedMagnesium Chloride Hydrate›Strength being verifiedCalcium Chloride Hydrate›Strength being verifiedPotassium Chloride›Strength being verifiedGlucose›Strength being verifiedSodium Acetate Hydrate›Strength being verified
Manufacturer / importer
(주)팜젠사이언스
Appearance
Contains 6 bags in 1 box (8 bags), and the characteristics of each bag are as follows: - Colorless or white powder packaged in three gray polyethylene film bags - Blue, red, brown
Packaging
29.273 kg
Approval status
Active

MFDS item code 201601188 · Notified 2016.02.29 · Insurance code 670103961

Summary

Main use
Treatment of chronic kidney failure through management of blood sugar levels and improvement of electrolyte imbalance
Who receives it
Adults
Adult administration
1) Preparation ① Place 60-72 L of distilled water into a suitable mixing container. ② Slowly add 1 packet of yellow bag (Sodium Acetate Hydrate) into the water and mix well. ③ Add 3 packets of gray bag (Sodium Chloride), 1 packet of blue bag (Magnesium Chloride Hydrate), 1 packet of red bag (Calcium Chloride Hydrate), 1 packet of brown bag (Potassium Chloride), and 1 packet of green bag (Glucose) into the mixing container from step ②. ④ Add enough distilled water to bring the total solution to 100 L.

Ingredients

Manufacturer
(주)팜젠사이언스

Efficacy & effects

Treatment of chronic kidney failure through management of blood sugar levels and improvement of electrolyte imbalance

  • Difficulty managing blood sugar levels
  • hyperkalemia
  • hypermagnesemia
  • hypercalcemia
View approved original text

This medication is a specialized perfusion solution used during artificial kidney dialysis in patients with chronic kidney failure. It is particularly necessary for patients who have difficulties managing blood sugar levels as they require a dialysis solution that does not contain sugar. It is also used instead of other bicarbonate-based dialysates when hyperkalemia or hypermagnesemia is persistent, or there is a risk of hypercalcemia. This helps manage possible electrolyte disturbances that may arise during dialysis. Ultimately, it is used to assist in the safe and effective treatment of hemodialysis.

How it is given

Adult administration

1) Preparation ① Place 60-72 L of distilled water into a suitable mixing container. ② Slowly add 1 packet of yellow bag (Sodium Acetate Hydrate) into the water and mix well. ③ Add 3 packets of gray bag (Sodium Chloride), 1 packet of blue bag (Magnesium Chloride Hydrate), 1 packet of red bag (Calcium Chloride Hydrate), 1 packet of brown bag (Potassium Chloride), and 1 packet of green bag (Glucose) into the mixing container from step ②. ④ Add enough distilled water to bring the total solution to 100 L.

Precautions

This medication should be used with caution in patients with severe liver impairment or severe diabetes, where acetate metabolism is compromised. If acetate is not properly metabolized, cardiac function may be suppressed, and vasodilation may occur, leading to hypotension. Patients taking digitalis preparations should monitor potassium serum levels as low potassium may lead to digitalis toxicity. Hypoglycemia or hyperglycemia may occur during or after dialysis, so appropriate actions should be taken immediately if blood sugar changes. Increased fluid intake due to thirst may lead to weight gain and elevated blood pressure, necessitating fluid and weight management. Bone complications such as osteoporosis or osteomalacia may arise, requiring treatment with active vitamin D3 preparations. Elevated phosphorus levels in the blood may lead to metastatic calcification, so phosphate binders should be used to maintain serum phosphorus levels within normal range. Dialysis disequilibrium syndrome may present symptoms such as headache, nausea, vomiting, seizures, and altered consciousness, requiring adjustments in dialysis intensity when these symptoms occur. Cardiovascular issues may result in hypotension or shock symptoms, so dialysis should be discontinued or adjusted if symptoms appear, and intravenous fluids or pressors should be administered as necessary. This medication is used for hemodialysis in chronic kidney failure patients when metabolic acidosis improvement or blood pressure reduction makes the use of conventional dialysate difficult. It is suitable for patients with difficulties in blood sugar control, containing glucose, and has low potassium, calcium, and magnesium concentrations to reduce the risk of hyperkalemia or hypercalcemia. Regular blood tests for monitoring electrolytes, acid-base balance, and blood sugar are essential. Pregnant women or those who could become pregnant should only use this medication when the benefits of treatment outweigh the risks. Safety in children has not been established, so it must be used cautiously. Elderly patients must thoroughly consider the characteristics of this medication and undergo regular evaluations to prevent bone complications during long-term use, and active vitamin D3 preparations should be administered as necessary. Water for preparing dialysis solutions must come from a strictly purified process, and care should be taken regarding potential dialysis membrane damage or bleeding tendencies. During preparation, do not mix electrolyte solutions for hemodialysis with sodium bicarbonate solutions, and dilute accurately to specified concentrations. Confirm the electrolyte concentrations and pH of the dialysis solution before use to ensure they are within appropriate ranges. The dialysis solution should be used as soon as possible after mixing, and should not be used if it has been more than 2 hours at 38 degrees Celsius, as insoluble materials may form. When using, adjust to a temperature suitable for body temperature, and it is not to be used for injection or peritoneal dialysis.

Side effects and when to seek care immediately

Serious side effects

  • Altered consciousness
  • seizures
  • altered consciousness
  • shock

Mild side effects

  • Hypoglycemia
  • hyperglycemia
  • weight gain
  • trend toward elevated blood pressure
  • osteoporosis
  • osteomalacia
  • fibrous osteitis
  • metastatic calcification
  • headache
  • nausea
Show 15 more
  • vomiting
  • seizures
  • altered consciousness
  • discomfort
  • fatigue
  • hypotension
  • shock
  • elevated blood pressure
  • headache
  • palpitations
  • altered consciousness
  • limb paralysis
  • general malaise
  • chest discomfort
  • sudden drop in blood pressure

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture, at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication.

Appearance and packaging

Appearance

Contains 6 bags in 1 box (8 bags), and the characteristics of each bag are as follows: - Colorless or white powder packaged in three gray polyethylene film bags - Blue, red, brown

Package unit

29.273 kg

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.