Morphine Injection 10mg/mL (Morphine Sulfate Hydrate)

Adult administration

This drug should be administered by subcutaneous injection, intramuscular injection, or slow intravenous injection, and must not be administered epidurally or intrathecally. When administering this drug intravenously, artificial resuscitation equipment and a narcotic antagonist (such as naloxone) should be kept immediately available. For patients with severe chronic pain, adjust the dose according to the severity of pain, response, and tolerance. The dose may be increased in patients with very severe chronic pain or those who are tolerant to the analgesic effects of narcotics. For elderly patients and patients receiving other central nervous system depressants, administer a reduced dose. This drug is primarily used for subcutaneous injection, but may also be administered by intramuscular injection or slow intravenous injection. Repeated subcutaneous injections may cause local inflammation, pain, and induration; therefore, intramuscular injection is preferred over subcutaneous injection for repeated administration. 1. Adults 1) Dose for subcutaneous or intramuscular injection: The usual dose is 10 mg of morphine sulfate hydrate every 4 hours as needed. A single dose of 5∼20 mg may be administered according to the patient's response and needs. 2) Dose for intravenous injection: The usual dose is 4∼10 mg of this drug, administered slowly over 4∼5 minutes, and repeated every 4 hours as needed. 2.5∼15 mg of this drug may be diluted in 4∼5 mL of sterile water for injection. 3. Pain relief during labor: The usual dose is 10 mg of this drug by subcutaneous or intramuscular injection. 4. Pain relief due to myocardial infarction: Inject 8∼15 mg of this drug. If the pain is very severe, additional small doses may be administered every 3∼4 hours.

Child administration

Inject 0.1∼0.2 mg/kg of this drug subcutaneously as needed; do not exceed 15 mg per dose. Do not administer to premature infants. The safety and efficacy in neonates have not been established.

This medication is a narcotic analgesic that acts on the central nervous system and should be used with caution if taken together with other central nervous system depressants or alcohol, as it may lead to severe sedation, respiratory depression, coma, and in severe cases, death. This medication should not be used if there are allergic reactions to it or in cases of seizures, chronic lung diseases, asthma attacks, severe respiratory depression, arrhythmias, brain tumors, acute alcohol intoxication, tremulous delirium, premature infants, or other specific conditions. Caution should be exercised when administering to patients with hypotension, respiratory depression, asthma, a history of drug dependence, ventricular tachycardia, acute abdominal conditions, ulcerative colitis, recent surgical patients, seizure disorders, increased intracranial pressure, severe liver and kidney dysfunction, fever, urinary disorders, hypothyroidism, adrenal insufficiency, children, and elderly patients. This medication can lead to dependence and tolerance, so long-term use requires close monitoring of the patient's condition, and sudden discontinuation can cause withdrawal symptoms. Drowsiness or dizziness may occur during treatment, so driving or operating dangerous machinery should be avoided. In patients with certain blood disorders, there is a risk of acute chest syndrome when using this medication, so careful monitoring is essential. This medication can cause adrenal insufficiency, and if related symptoms occur, appropriate treatment is necessary. Long-term use may lead to symptoms related to decreased sex hormones. High-dose usage may result in pain hypersensitivity, requiring dose adjustments. It may cause sleep apnea and hypoxia; therefore, patients with these symptoms or those worsening them should consider gradually decreasing the dose or discontinuation. Side effects related to the biliary tract and pancreas may occur, so watch for related symptoms. Severe skin reactions have been reported; therefore, if any abnormal symptoms such as rash or itching occur, consult a healthcare professional immediately. When combined with other central nervous system depressants, narcotic analgesics, antidepressants, neuromuscular blockers, etc., the risk of side effects may increase, so it is essential to consult with healthcare professionals. During pregnancy, it may affect the fetus, so it should only be administered when absolutely necessary, with close monitoring of potential respiratory depression in the newborn during childbirth. During breastfeeding, this medication can be excreted in breast milk, necessitating cessation of breastfeeding. Caution should be taken when administering to children and the elderly, especially as children may be more sensitive to respiratory depression, requiring dosage adjustments and surveillance. In cases of overdose, there is a risk of severe respiratory depression, loss of consciousness, hypotension, and immediate emergency treatment should be sought, administering narcotic antagonists if necessary. Before administration, check for discoloration or sediment in the solution; if abnormal, do not use. This medication has a risk of abuse, requiring special attention in use and storage. In case of skin exposure, it should be rinsed immediately. This medication should be stored in a tightly sealed container to block light and kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain its effectiveness and prevent degradation.

Yawn, sneeze, tearing, sweating, nausea, vomiting, diarrhea, abdominal pain, pupil dilation, headache, insomnia, anxiety, hallucinations, seizures, tremors, pain in muscles and joints throughout the body, respiratory distress, palpitations, shortness of breath, slow breathing, irregular breathing, apnea, weakness, tremors, muscle coordination disorder, temporary hallucinations, loss of orientation, visual impairment, headache, agitation, discomfort, abnormal euphoria, sedation, dizziness, dysentery, hyperalgesia, sweating, nausea, vomiting, constipation, biliary colic, increased colonic motility, increased toxicity, dry mouth, pancreatitis, sphincter of Oddi spasm, tachycardia, bradycardia, palpitations, confusion, syncope, orthostatic hypotension, oliguria, urinary retention, itching, urticaria, rash, acute generalized exanthematic pustulosis, central sleep apnea syndrome, flushing, sweating, localized itching, pain, sclerosis, intestinal obstruction, respiratory depression, unresponsiveness, coma, skeletal muscle relaxation, cold skin, miosis, bradycardia, hypotension, apnea, cardiovascular collapse, cardiac arrest, death, aspiration pneumonia

This medication must be stored in a sealed container that blocks light, and it is safe to store at room temperature between 1 degree and 30 degrees Celsius. By doing so, the medication's efficacy is well maintained, preventing degradation.

Appearance

A colorless, transparent solution in a brown, transparent ampoule.

Package unit

1mL X 25 ampoules