Klaisyn Tablets 250mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. For patients with renal impairment and creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and administer omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children 12 years of age and older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be administered to certain patients. For example, it should not be used in patients with allergies to the components of this drug or a history of hypersensitivity to similar classes of antibiotics. It should also not be given to patients taking certain heart-related medications, those with heart diseases, patients with severely impaired liver or kidney function, and pregnant or nursing women. This drug must be used with caution in patients with decreased liver and kidney function, elderly patients, and those taking other antibiotics. If any abnormal reactions occur, such as allergic symptoms, severe diarrhea, skin rashes, or respiratory distress during the course of this medication, discontinue use immediately and consult a physician. Gastrointestinal disturbances, liver function abnormalities, kidney issues, and symptoms related to the central nervous system may occur rarely, so careful observation is required if such symptoms arise. This drug has a high potential for drug interactions, so if other medications are being taken, it is essential to inform the doctor or pharmacist. Caution is especially necessary when used with medications that may cause arrhythmias, affect liver metabolism, hypoglycemic agents, or anticoagulants. Pregnant or nursing women should not take this drug; if necessary, breastfeeding should be discontinued. Caution is required for use in children, especially under 12 years old, as safety and effectiveness have not been fully established in this age group. In elderly individuals, dosage adjustments may be necessary due to potential increases in drug concentration due to renal function decline. In cases of overdose, gastrointestinal disturbances or mental symptoms may occur, necessitating immediate medical attention.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, decreased appetite, constipation, discoloration of stools, membrane colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, increased eosinophils, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, abnormal urine color

This drug should be stored in a tightly sealed container to protect it from air or moisture, and it is safe to keep it at room temperature between 1 to 30 degrees Celsius. Therefore, avoid very hot or very cold places, and it is best to store it in a cool place away from direct sunlight.

Appearance

Yellow rectangular film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle