Dongseong Famciclovir Tablet 250 mg (Famciclovir)

Adult dose

1. Treatment of herpes zoster infection Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this medicine orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this medicine orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine orally twice daily. Periodically discontinue treatment every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the clearance of this medicine is reduced in patients with renal impairment, dosage adjustment should be made with care. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily 10～29: 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg per dose twice daily 10～29: 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg per dose twice daily 10～29: 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients on hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Four hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dosage adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be taken by individuals allergic to this medication or its ingredients. Additionally, this medication contains lactose, so patients with a genetic inability to digest lactose should also avoid taking it. Patients with impaired kidney function should use this medication with caution. Mild side effects such as headaches or nausea may occur while taking this medication, but they are generally not severe. Rarely, there may be symptoms such as decreased blood cell counts, mental confusion, hallucinations, dizziness, or drowsiness. Gastrointestinal effects may lead to nausea, vomiting, abdominal pain, and diarrhea. Liver function abnormalities and skin reactions such as rashes and itching are also commonly reported. In patients with poor kidney function, acute renal failure may occur, necessitating dose adjustments. This medication does not cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices when symptoms are present. If dizziness or drowsiness occurs during treatment, driving or operating machinery should be avoided. Generally, elderly patients do not require dose adjustments, but dose adjustments may be necessary in cases of decreased kidney function. In cases of overdose, appropriate medical treatment is necessary, and blood dialysis can partially remove the active ingredient of this medication. This medication should be stored in a dry place below 30 degrees Celsius and kept out of reach of children. Transferring this medication to another container may cause accidents or quality degradation, so caution is advised.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be kept in a tightly sealed container to avoid exposure to air and moisture. It is best stored in a cool, dry place below 30 degrees Celsius away from direct sunlight.

Appearance

White round film-coated tablet

Package unit

21 tablets/PTP