Disolin Tablet (Methylprednisolone)

Adult use

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, but a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. If a satisfactory clinical result is not obtained after a reasonable period, discontinue treatment and switch to another appropriate therapy. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, determine the appropriate maintenance dose by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. The dose must be monitored continuously. Dose adjustment may be necessary in situations such as improvement or worsening of the disease, the individual patient's response to the medicine, or the effects on the patient of exposure to stress unrelated to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to achieve satisfactory control of the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the medicine. Multiple sclerosis For treatment of acute exacerbations of multiple sclerosis, administration of prednisolone 200mg daily for 1 week followed by prednisolone 80mg every other day for 1 month is effective (4mg of methylprednisolone is equivalent to 5mg of prednisolone). ADT (Alternate Day Therapy) Alternate day therapy means administering twice the daily dose on one morning every other day. Although a single morning dose of prednisolone (10mg) causes considerably less adrenal suppression than taking it in 4 divided doses every 6 hours, there is evidence that, when pharmacological doses are used, a slight suppressive effect on adrenal activity continues into the following day. The initial suppressive dose should be continued until a satisfactory clinical response is achieved, usually for 4 to 10 days in many allergic and collagen diseases. If difficulties arise, it is preferable to administer 3 or even 4 times the daily dose every other day rather than simply twice the daily dose.

This medication should not be administered to certain patients. First, it should not be used in patients who have had allergic reactions to this medication or any of its components. Also, this medication should not be given to patients with infections without appropriate antimicrobials or systemic fungal infections, as it may exacerbate the infection. It should not be used in patients with herpes simplex, shingles, or chickenpox, nor in patients currently receiving live vaccines or attenuated live vaccines. Patients who require cautious administration include those with glaucoma as this medication may raise intraocular pressure and worsen the condition. Patients with tuberculous diseases, keratitis, or posterior capsule cataract should also be cautious as this medication may exacerbate symptoms. Additionally, patients with electrolyte abnormalities, hypertension, thrombosis, those who have recently undergone bowel anastomosis, or have a history of acute myocardial infarction also need careful management. Patients with peptic ulcers, mental illness, or severe osteoporosis should exercise caution as this medication may worsen symptoms. This medication suppresses immune function, thus it should be used cautiously in patients with infections, diabetes, renal failure or congestive heart failure, hypothyroidism, hepatic steatosis or fat embolism, severe myasthenia gravis, the elderly, patients with epilepsy, and those with ulcerative colitis. Side effects may include edema, sodium retention, potassium loss, and fluid and electrolyte imbalances, as well as muscle weakness, osteoporosis, arthralgia, skin changes, gastrointestinal disorders, psychiatric nervous system symptoms, endocrine disorders, elevated intraocular pressure, and glaucoma. Allergic reactions or, in severe cases, shock may occur, so symptoms should be closely monitored. When used long-term, adrenal function may decline, and abruptly stopping the medication can lead to serious side effects, thus it should be tapered off slowly. Also, in stressful situations such as surgery or infection, the dosage may need to be temporarily increased. During the use of this medication, one should avoid exposure to infections such as chickenpox or measles, and immediately seek treatment if infection is suspected or occurs. Live vaccinations should be avoided during medication administration, and caution should be exercised in environments with a high risk of infection. This medication may interact with many other drugs, so if you are taking other medications, you must consult with your doctor or pharmacist. Caution is especially needed when used with heart-related drugs, anticoagulants, hypoglycemics, diuretics, antibiotics, and antifungals. Women who are pregnant or may become pregnant should only use this medication when the benefits of treatment outweigh the risks to the fetus. Additionally, this medication is transmitted through breast milk, so breastfeeding mothers should avoid its use. In children, side effects such as growth retardation may occur, so it should be used at the minimal dose with close monitoring. Elderly patients are at a higher risk for side effects such as infections, diabetes, osteoporosis, hypertension, cataracts, and glaucoma, so administration should be especially cautious. Finally, this medication contains lactose, so it should not be used in patients with lactose intolerance or certain hereditary metabolic disorders.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of the femoral and humeral epiphyses, steroid myopathy, loss of muscle mass, pathological fracture of the pelvis, osteoporosis, vertebral compression fracture, arthralgia, tendon rupture, elevated ALT, elevated AST, elevated ALP, nausea, dry mouth, vomiting, abdominal pain, loss of appetite, increased appetite, peptic ulcer, abdominal bloating, pancreatitis, ulcerative esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, purpura, skin reaction suppression, purpura, acne, hirsutism, hair loss, pigmentation, nipple swelling, increased intracranial pressure, convulsions, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression, symptoms of latent diabetes, secondary adrenal insufficiency, pituitary unresponsiveness, decreased glucose tolerance, increased requirement for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior capsule cataract, secondary infection of the eye due to fungi or viruses, retinal disorders, exophthalmos, nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reaction, hypersensitivity reaction

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius.

Appearance

White round tablet

Package unit

30 tablets/bottle, 500 tablets/bottle