Linomet Tablet 50/1000 mg

Adult dose

In antidiabetic therapy, the dosage should be determined within the range not exceeding sitagliptin 100 mg and metformin 2000 mg, considering the patient's treatment regimen, efficacy, and tolerability. Generally, it is taken twice daily with food and the dosage should be gradually increased to reduce gastrointestinal adverse reactions associated with metformin. The initial dose varies depending on the patient's treatment regimen. 1. Patients without prior metformin treatment: The initial dose is this

This medication contains sitagliptin and metformin, which aid in blood sugar control. First, this medication may cause hypersensitivity reactions; therefore, if symptoms such as skin rashes, hives, or difficulty breathing occur, stop taking it immediately and consult a physician. Additionally, acute pancreatitis may occur; hence, if abdominal pain, vomiting, or severe abdominal discomfort arises, inform healthcare providers immediately. This medication is not safely administered to patients with decreased kidney function, especially in cases where creatinine clearance or glomerular filtration rate is low. It should also be avoided in conditions such as severe infection, dehydration, heart failure, or acute myocardial infarction. Patients undergoing radiologic iodine contrast studies should discontinue this medication for a specified period before and after the exam and can resume after kidney function is restored. Women who are pregnant or of childbearing age, as well as nursing mothers, should avoid using this medication. This medication may cause hypoglycemia; hence, blood sugar levels should be carefully monitored when meals are skipped, meals are irregular, or excessive exercise is undertaken. Particularly, when taken with insulin or sulfonylureas, the risk of hypoglycemia may increase, so dose adjustments should be made according to physician's instructions. The metformin component can rarely cause a serious side effect known as lactic acidosis. If symptoms such as difficulty breathing, muscle pain, fatigue, or abdominal pain occur, consult healthcare providers immediately. Patients with impaired liver function or those consuming excessive alcohol should be cautious as the risk of lactic acidosis increases. Regular blood tests and kidney function tests should be performed while taking this medication, and supplementation for vitamin B12 deficiency may be necessary if it occurs. It is advised to pause taking this medication for a designated period before and after surgery and to restart only after the patient's condition stabilizes and kidney functions are confirmed normal. This medication has not been established for safety and efficacy in children, and elderly patients may face a risk of impaired kidney function, so dose adjustments and regular kidney function checks are necessary. In case of overdose, immediate medical attention should be sought for appropriate treatment, and dialysis may be required. Lastly, it is advised to avoid alcohol consumption while taking this medication, and to inform healthcare providers of any concurrent medication as interactions may occur.

Serious side effects

Hives, severe hypersensitivity reactions (including anaphylaxis, angioedema, Stevens-Johnson syndrome), acute pancreatitis, severe lactic acidosis, hypoglycemia, severe skin adverse reactions (severe rash with fever, blistering, desquamation, mucosal pain), difficulty breathing, acute kidney failure, severe edema, serious neurological symptoms (headache, confusion), severe and debilitating joint pain, bullous pemphigoid-like rash

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• myalgia
• limb pain
• back pain

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at room temperature between 1 degree and 30 degrees Celsius. This will help maintain the medication's effectiveness for a long time.

Appearance

Dark red oval film-coated tablet

Package unit

28 tablets (14 tablets/PTPX2), 56 tablets (14 tablets/PTPX4)