Dongkuk Ceftriaxone Injection 1 Gram (Sodium Ceftriaxone Hydrate)

Adult administration

Adults and children over 12 years: Administer 1-2 g (potency) of ceftriaxone once a day by intravenous or intramuscular injection. For infections caused by severe pathogens or those with moderate sensitivity, the dose can be increased up to 4 g (potency) once daily. For gonorrhea treatment, a single intramuscular injection of 250 mg (potency) is recommended. For prevention of infections before and after surgery, administer 1-2 g (potency) as a single dose 30-90 minutes before the surgery.

Child administration

Neonates (up to 14 days old): Administer 20-50 mg (potency) per kg of body weight once a day, not exceeding 50 mg (potency). Infants and children (15 days to 12 years): Administer 20-80 mg (potency) per kg of body weight once a day. For children over 50 kg, the adult dosage should be administered, and if administering over 50 mg (potency) per kg intravenously, it should be given as an infusion for at least 30 minutes.

This drug should be administered separately, as mixing or administering with calcium-containing solutions or other medications can lead to dangerous precipitates. Especially in newborns, co-administration with calcium-containing solutions may create fatal precipitates affecting the lungs and kidneys, so it should be avoided. Patients with hypersensitivity to this drug or allergies to cephalosporins, penicillin antibiotics, or certain local anesthetics should not be administered this drug. This drug should not be used in premature infants or newborns with bilirubin binding disorders, or newborns receiving calcium-containing solutions. Patients with a history of hypersensitivity or allergic constitution, severely impaired renal function, and elderly patients in poor general condition should be administered with caution, and dosage adjustments or tests should be performed as needed. This drug may cause various side effects such as decreased blood cell count, diarrhea, rash, increased liver enzymes, etc., so if any abnormal symptoms occur, consult medical staff immediately. Severe allergic reactions or shock may occur, thus thorough medical history taking and observation are necessary before administration, and emergency measures should be prepared. For prolonged or high-dose use, it is important to regularly conduct liver and kidney function tests as well as blood tests. This drug may interact with other medications, so caution is required, especially when used with diuretics, aminoglycoside antibiotics, vitamin K antagonists, etc. Pregnant or nursing mothers should use this drug cautiously as its administration may affect the fetus or newborn. In newborns and premature infants, there is a risk of bilirubin encephalopathy, so this drug is not recommended for use. Elderly patients are at increased risk of side effects due to diminished physiological function, so dosages and administration intervals should be adjusted while closely monitoring. This drug can cause pain in the veins or phlebitis when injected intravenously, thus attention to the injection speed and method is necessary, and it should be used as soon as possible after preparation. This drug and calcium-containing solutions should not be administered through the same injection port and the infusion line must be thoroughly flushed during administration. In case of overdose, there are no specific antidotes, so symptomatic treatment according to symptoms is necessary, and caution should be exercised regarding dizziness and other side effects when driving or operating machinery.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever accompanied by severe rashes, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme fatigue, liver abnormalities (jaundice), sudden and very severe

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• dizziness
• bronchospasm
• nausea
• vomiting

This drug should be stored in a sealed container to protect it from air, and it is best to keep it at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the drug's effectiveness.

Appearance

A colorless transparent glass vial filled with a white to pale yellow crystalline powder

Package unit

1 gram/vial x 10